gene 527 words KG: CD163
Contents

CD163 (Hemoglobin Scavenger Receptor)

🧬 Gene Info
Gene SymbolCD163
Full NameCD163 Molecule (Hemoglobin Scavenger Receptor)
AliasesHemoglobin Scavenger Receptor
Chromosome12p13.31
Protein TypeReceptor
FunctionCD163 (Cluster of Differentiation 163), also known as the Hemoglobin Scavenger Receptor, is a member of the scavenger receptor family.
PathwaysTGF-β
UniProt ID[Q86VB7](https://www.uniprot.org/uniprot/Q86VB7)
Ensembl IDENSG00000177575
GeneCardsCD163
Human Protein AtlasCD163
Extracellular domain9 scavenger receptor cysteine-rich (SRCR) domains
Transmembrane regionSingle pass
Cytoplasmic tailSignaling capabilities
Associated DiseasesAging, ALS, Cancer, Inflammation, Ms, Neuroinflammation
InteractionsAKT, AMPK, AND, APOC1, APOE, App
KG Connections315 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Oligodendrocyte White Matter Vulnerability
Score: 0.65
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
ARG1 — Arginase 1
gene · KG edge: expressed_in
C1QA Gene
gene · KG edge: activates
C1QB — Complement Component 1Q Beta
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CD163 biomarker_for MMP9
CD163 associated_with CD14
CD163 associated_with CD68
CD163 biomarker_for MMP2
CD36 activates CD163
NRF2 activates CD163
CX3CR1 activates CD163
TNF activates CD163
CD163 activates CD68
CD68 associated_with CD163

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