gene 1,750 words KG: ITGAM
Contents

ITGAM Gene

🧬 Gene Info
Gene SymbolITGAM
Protein TypeReceptor
Functionis a multifunctional immune receptor that binds complement fragment iC3b, ICAM-family ligands, fibrinogen, and damage-associated molecular patterns.
Amino Acids1153 aa
PathwaysComplement
Ensembl IDENSG00000169896
GeneCardsITGAM
Human Protein AtlasITGAM
Associated DiseasesAging, Als, Alzheimer, Parkinson's disease, Senescence
InteractionsAIF1, AND, APOPTOSIS, C1QA, C1QB, C1QC
SciDEX HypothesesITGAM/CD11b direct binding explains microglial pha
KG Connections202 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
pg 1/2Next →

Related Analyses (7)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

See Also (13)

AIF1 Gene
gene · KG edge: biomarker_for
C1QA Gene
gene · KG edge: biomarker_for
C1QB — Complement Component 1Q Beta
gene · KG edge: biomarker_for
C1QC
gene · KG edge: activates
C1R — Complement Component 1, R Subcomponent
gene · KG edge: regulates

Knowledge Graph (12 edges)

ICAM1 activates ITGAM
TREM2 activates ITGAM
TLR2 activates ITGAM
NFKBIA activates ITGAM
MRC1 activates ITGAM
IL1B activates ITGAM
ITGAM activates TNF
ITGAM activates CXCL2
ITGAM activates CD14
ITGAM activates PPARG

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.