gene 1,593 words KG: GNAL
Contents

GNAL — Gαolf Subunit

🧬 Gene Info
Gene SymbolGNAL
Full NameGαolf Subunit
Chromosome18p11.21
Functionencodes the Gαolf protein (Guanine nucleotide-binding protein subunit alpha L), a member of the Gαs family of heterotrimeric G proteins
Primary ExpressionNeuron-specific (olfactory epithelium, striatum)
Molecular Weight44 kDa
Exons12
UniProt ID[P38405](https://www.uniprot.org/uniprot/P38405)
Ensembl IDENSG00000141449
GeneCardsGNAL
Human Protein AtlasGNAL
Chromosomal location18p11.21
Genomic span~67 kb, 12 exons
Associated DiseasesAls
InteractionsCAMKII, CCND1, CYTOKINES, IL1B, IL3, IL8
KG Connections145 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (187)

Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
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Sphingolipid Metabolism Reprogramming
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TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Glycosaminoglycan Template Disruption Approach
Score: 0.60
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
Netrin-1 Gradient Restoration
Score: 0.59
VCP-Mediated Autophagy Enhancement
Score: 0.59
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
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Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussed
Amyotrophic Lateral Sclerosis
redirect · KG edge: co_discussed
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
Apoptosis in Neurodegeneration
entity · KG edge: co_discussed
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: co_discussed

Knowledge Graph (12 edges)

GNAL expressed_in VAMP7
GNAL expressed_in MMP9
GNAL inhibits PI3K
GNAL associated_with AKT
GNAL associated_with AKT1
GNAL expressed_in MCC
GNAL expressed_in CXCR4
GNAL associated_with ALDH1A3
GCH1 associated_with GNAL
THAP1 associated_with GNAL

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