gene 1,593 words KG: GNAL
Contents

GNAL — Gαolf Subunit

🧬 Gene Info
Gene SymbolGNAL
Full NameGαolf Subunit
Chromosome18p11.21
Functionencodes the Gαolf protein (Guanine nucleotide-binding protein subunit alpha L), a member of the Gαs family of heterotrimeric G proteins
Primary ExpressionNeuron-specific (olfactory epithelium, striatum)
Molecular Weight44 kDa
Exons12
UniProt ID[P38405](https://www.uniprot.org/uniprot/P38405)
Ensembl IDENSG00000141449
GeneCardsGNAL
Human Protein AtlasGNAL
Chromosomal location18p11.21
Genomic span~67 kb, 12 exons
Associated DiseasesAls
InteractionsCAMKII, CCND1, CYTOKINES, IL1B, IL3, IL8
KG Connections145 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (187)

Purinergic Signaling Polarization Control
Score: 0.71
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
APOE-Dependent Autophagy Restoration
Score: 0.88
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
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Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussed
Amyotrophic Lateral Sclerosis
redirect · KG edge: co_discussed
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
Apoptosis in Neurodegeneration
entity · KG edge: co_discussed
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: co_discussed

Knowledge Graph (12 edges)

GNAL expressed_in VAMP7
GNAL expressed_in MMP9
GNAL inhibits PI3K
GNAL associated_with AKT
GNAL associated_with AKT1
GNAL expressed_in MCC
GNAL expressed_in CXCR4
GNAL associated_with ALDH1A3
GCH1 associated_with GNAL
THAP1 associated_with GNAL

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