| Gene Symbol | CXCR4 |
| Aliases | C-X-C chemokine receptor type 4 |
| Chromosome | 2q22.1 |
| Protein Type | Receptor |
| Function | CXCR4 has diverse physiological roles |
| Molecular Weight | 39.8 kDa |
| Amino Acids | 352 aa |
| Pathways | NF-κB, PI3K, MAPK pathway, MAPK |
| GeneCards | CXCR4 |
| Human Protein Atlas | CXCR4 |
| Seven transmembrane helices (TM1-7) | Form the ligand-binding pocket |
| N-terminal domain | Contains sulfated tyrosine residues critical for CXCL12 binding |
| C-terminal tail | Contains phosphorylation sites for β-arrestin recruitment and desensitization |
| Extracellular loops (ECL1-3) | Contribute to ligand specificity |
| Intracellular loops (ICL1-3) | Mediate G protein coupling (primarily Gi/o) |
| Associated Diseases | Als, Alzheimer, Autoimmune, Breast Cancer, Cancer, dementia |
| Interactions | AGING, ALZHEIMER'S DISEASE, APOE, APOPTOSIS, APP, AUTOPHAGY |
| KG Connections | 301 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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