gene 3,043 words KG: BIN1
Contents

BIN1 — Bridging Integrator 1

🧬 Gene Info
Gene SymbolBIN1
Full NameBridging Integrator 1
Chromosome2q14.3
Functionis a gene located on chromosome 2q14.
Primary ExpressionCerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight70 kDa
Exons20
PathwaysAutophagy, Complement, Endocytosis, proinflammatory activation
UniProt IDO00499
NCBI Gene ID274
Ensembl IDENSG00000136717
OMIM601248
GeneCardsBIN1
Human Protein AtlasBIN1
Associated Diseasesaging, Als, Alzheimer, Alzheimer disease
InteractionsABCA7, Actin, AD, ADAM10, ADAMTS4, AGING
KG Connections1000 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
← Prevpg 2/2

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BIN1 regulates phosphorylated tau
CD8 expressed_in BIN1
STAT1 activates BIN1
BIN1 activates G3BP1
EPAS1 associated_with BIN1
CACNG6 associated_with BIN1
BIN1 therapeutic_target CHRNA2
BIN1 associated_with CEBPA
BIN1 therapeutic_target CNR1
BIN1 associated_with CTSD

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