| Gene Symbol | CHRNA2 |
| Full Name | Cholinergic Receptor Nicotinic Alpha 2 |
| Chromosome | 8p21 |
| Protein Type | Receptor |
| Function | is a member of the Cys-loop receptor superfamily, which also includes GABAₐ, glycine, and 5-HT₃ receptors. |
| Primary Expression | both the central and peripheral nervous systems, where they mediate fast synaptic transmission and modulate neuronal excitability |
| Molecular Weight | 56 kDa |
| UniProt ID | [P43681](https://www.uniprot.org/uniprotkb/P43681) |
| Ensembl ID | ENSG00000120288 |
| GeneCards | CHRNA2 |
| Human Protein Atlas | CHRNA2 |
| Extracellular N-terminal domain | Contains the acetylcholine binding site |
| Transmembrane domain | Four α-helices (M1-M4) forming the ion channel pore |
| Intracellular loop | Between M3 and M4, contains phosphorylation sites |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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