concept

LIPID PEROXIDATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPID PEROXIDATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

142Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

8Experiments

2Debates

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💡 Concept Info

Name	LIPID PEROXIDATION
Key Genes/Proteins	ACSL4, APOE, APOE4, ATG5, BECN1
Related Diseases	ALZHEIMER'S DISEASE, APOPTOSIS, ATP, CELL DEATH, DOPAMINE
Related Pathways	CALCIUM SIGNALING

Pathway Diagram

graph TD
    LIPID_PEROXIDATION["LIPID PEROXIDATION"]
    LIPID_PEROXIDATION -->|"involved_in"| Ferroptosis["Ferroptosis"]
    LIPID_PEROXIDATION -->|"causes"| Cellular_Membrane_Destruction["Cellular Membrane Destruction"]
    LIPID_PEROXIDATION -->|"causes"| Ferroptotic_Cell_Death["Ferroptotic Cell Death"]
    LIPID_PEROXIDATION -->|"causes"| Lysosomal_Damage["Lysosomal Damage"]
    LIPID_PEROXIDATION -->|"causes"| Lipofuscinosis["Lipofuscinosis"]
    NADPH["NADPH"] -->|"inhibits"| LIPID_PEROXIDATION
    Ferroptosis -->|"mediates"| LIPID_PEROXIDATION
    ZnONPs["ZnONPs"] -->|"causes"| LIPID_PEROXIDATION
    GPX4["GPX4"] -->|"inhibits"| LIPID_PEROXIDATION
    Ferrostatin_1["Ferrostatin-1"] -->|"inhibits"| LIPID_PEROXIDATION
    AMPK["AMPK"] -->|"inhibits"| LIPID_PEROXIDATION

Outgoing (63)

Target	Relation	Type	Str
Cellular Membrane Destruction	causes	phenotype	0.95
Ferroptosis	involved_in	process	0.95
Ferroptosis	contributes_to	process	0.95
Lipofuscinosis	causes	phenotype	0.90
Ferroptosis	biomarker_for	process	0.90
Lysosomal Damage	causes	process	0.90
Ferroptosis	mediates	process	0.90
ferroptosis	drives	process	0.90
Ferroptotic Cell Death	causes	process	0.90
metabolic dysfunction-associated fatty liver disease	drives	disease	0.88
Ferroptosis	associated_with	process	0.85
Thromboinflammation	contributes_to	process	0.85
IFNB	upregulates	gene	0.85
ferroptosis	upstream_of	process	0.80
STING	inhibits	protein	0.80
Microglial activation	activates	process	0.70
NEUROINFLAMMATION	inhibits	phenotype	0.70
ferroptosis	activates	process	0.70
OXIDATIVE STRESS	activates	phenotype	0.70
Mitochondrial damage	causes	mechanism	0.70
neurodegeneration	causes	process	0.70
Protein aggregation	enhances	mechanism	0.70
NEUROINFLAMMATION	regulates	phenotype	0.65
NEURONS	treats	cell_type	0.65
TAU	phosphorylates	protein	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
GLUTAMATE	inhibits	phenotype	0.65
HMGCR	treats	gene	0.65
FERROPTOSIS	treats	phenotype	0.65
INSULIN RESISTANCE	treats	phenotype	0.65
GPX4	regulates	gene	0.65
ACSL4	activates	gene	0.65
ACSL4	regulates	gene	0.65
GPX4	causes	gene	0.65
UBIQUITIN	activates	protein	0.65
OXIDATIVE STRESS	biomarker_for	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
ALZHEIMER'S DISEASE	degrades	disease	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
ROS	treats	phenotype	0.65
NEURONS	activates	cell_type	0.65
FERROPTOSIS	protects_against	phenotype	0.65
ATP	regulates	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
CALCIUM SIGNALING	protects_against	pathway	0.65
NEURONS	protects_against	cell_type	0.65
MICROGLIAL ACTIVATION	regulates	phenotype	0.65
NEURODEGENERATION	participates_in	disease	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
NEURODEGENERATION	implicated_in	disease	0.55

Incoming (79)

Source	Relation	Type	Str
ferroptosis	causes	process	0.95
Ferroptosis	mediates	process	0.92
Ferrostatin-1	inhibits	compound	0.90
ROS	causes	process	0.90
Sbfi26	promotes	drug	0.90
AMPK	inhibits	protein	0.90
Oxidative Stress	causes	process	0.90
NQO1	inhibits	gene	0.90
GSR	inhibits	gene	0.90
Myelin Debris	promotes	compound	0.90
GPX4	catalyzes	protein	0.90
ZnONPs	causes	drug	0.90
GPX4	inhibits	protein	0.90
Alox12	drives	protein	0.90
Cadmium	associated_with	compound	0.90
L-Carnitine	downregulates	compound	0.90
TP53	promotes	gene	0.85
Alox12	promotes	protein	0.85
L-Carnitine	inhibits	compound	0.85
TP53	upstream_of	gene	0.85
Fatty Acids	contributes_to	compound	0.85
Ferroptosis	associated_with	process	0.85
Lipid Antioxidants	protects_against	compound	0.85
Superoxide Anion Free Radicals	causes	compound	0.85
ferroptosis	mediates	process	0.85
Ferrous Ions	contributes_to	compound	0.85
FSP1	inhibits	protein	0.85
Myelin Debris	causes	compound	0.85
Liproxstatin-1	inhibits	drug	0.85
Ferrous Ions	promotes	compound	0.85
Fatty Acid Accumulation	associated_with	phenotype	0.80
Iron Imbalance	causes	process	0.80
Chronic Cerebral Hypoperfusion	associated_with	process	0.80
Endolysosomal Targeting	mediates	process	0.80
Chronic Cerebral Hypoperfusion	exacerbates	condition	0.80
SBFI26	associated_with	chemical	0.80
SENESCENCE	regulates	phenotype	0.70
WHITE MATTER	causes	brain_region	0.70
ALOX15	enhances	protein	0.70
TH	activates	gene	0.70
Ferroptosis	causes	pathway	0.70
BECN1	activates	gene	0.65
GPX4	treats	gene	0.65
APOE	interacts_with	gene	0.65
CELL DEATH	causes	phenotype	0.65
ATG5	causes	gene	0.65
ATG5	activates	gene	0.65
NEURONS	causes	cell_type	0.65
DOPAMINE	causes	phenotype	0.65
TNF	phosphorylates	gene	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Iron-driven lipid peroxidation and GPX4 failure create a fer	0.750	neurodegeneration	What mechanisms drive the self-amplifyin
Senescence-Induced Lipid Peroxidation Spreading	0.730	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (2)

Scientific analyses that reference this entity

Is ferroptosis the primary driver of motor neuron death in ALS or an epiphenomen

neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Iron Dyshomeostasis in MSA Pathogenesis Experiment	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,280,000
Peroxisomal Dysfunction Validation in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Peroxisome Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Discovery of a glycosylated colchicine derivative as a neuroprotective agent for [PMID:41455281]	["Jash M", "Gupta S", "Garg S", "Khan J"	European journal of medicinal	2026	0
The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves ca [PMID:41671579]	Wang J, Li CM, Yang B, Tantai RN, Guo HX	British journal of pharmacolog	2026	0
From association to mechanism: Prenatal PFAS Co-exposures induces fetal neural t [PMID:41485332]	Chen Y, Cheng Q, Yang C, Li S, Lin H, Li	Journal of hazardous materials	2026	0
Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses i [PMID:41540498]	Fang F, Xu Q, Shen S, Wang S, Bao C	European journal of medical re	2026	0
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis [PMID:41822239]	Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z	Food science & nutrition	2026	0
Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporo [PMID:41016294]	["Hu L", "Luo M", "Zhu X", "Wang Z", "Ya	Phytomedicine : international	2025	0
Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614]	["Jin H", "Xue B", "Chen X", "Ma T", "Ma	Environmental pollution (Barki	2025	0
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferropt [PMID:40214929]	["Zhang Y", "Tang Q", "Yao J", "Liu H",	Journal of neuroimmune pharmac	2025	0
Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-me [PMID:41080723]	["Liu Q", "Zhang J", "Yu L", "Chen Y", "	Materials today. Bio	2025	0
Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradat [PMID:39503881]	["Guo L", "Yang Y", "Ma J", "Xiao M", "C	Cell biology and toxicology	2024	0
Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST me [PMID:38906233]	["Shi Y", "Xu N", "Liu B", "Ma Y", "Fu X	Free radical biology & medicin	2024	0
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to D [PMID:37679058]	["Liu C", "Wang Y", "Zeng Y", "Kang Z",	Advanced science (Weinheim, Ba	2023	0
In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. [PMID:35384401]	["Ide K", "Souma T"]	Current protocols	2022	0
Commentary: Toward Less Traumatic, Not Just Less Invasive, Surgery [PMID:33188881]	Bremner Ross M	Seminars in Thoracic and Cardi	2021	0
En masse DNA Electroporation for in vivo Transcriptional Assay in Ascidian Embry [PMID:34692910]	Darras S	Bio-protocol	2021	0
Management of primary aldosteronism and mineralocorticoid receptor-associated hy [PMID:32424201]	["Morimoto S", "Ichihara A"]	Hypertension research : offici	2020	0

Debates (2)

Multi-agent debates referencing this entity

The debate highlighted compelling correlative evidence for ferroptosis markers i

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

closed · Rounds: 5 · Score: 0.59 · 2026-04-16