process

Gut Microbiome

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Gut Microbiome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

271Connections

5Hypotheses

0Analyses

27Outgoing

50Incoming

0Experiments

0Debates

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🧬 Biological Process Info

Name	Gut Microbiome
Key Genes/Proteins	AGING, AHR, AKT, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALS
Related Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease
Linked Hypotheses	2 hypotheses

Wiki Pages (4)

Knowledge base pages for this entity

Gut Microbiome-Based Therapy for Neurodegeneration

therapeutic · 3319 words

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NCT06487975: Bacillus Subtilis Gut Microbiome Intervention for PD

clinical · 1594 words

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Gut Microbiome-Derived Lipids and Alpha-Synuclein Aggregation in Parkinson's Disease

mechanism · 1181 words

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Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propagation

experiment · 992 words

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Pathway Diagram

graph TD
    Gut_Microbiome["Gut Microbiome"]
    Neurodegeneration_Progression["Neurodegeneration Progression"]
    Gut_Microbiome -->|"modulates"| Neurodegeneration_Progression
    Als{"Als"}
    Als -->|"activates"| Gut_Microbiome
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"activates"| Gut_Microbiome
    Inflammation{"Inflammation"}
    Inflammation -->|"activates"| Gut_Microbiome
    style Gut_Microbiome fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Short-Chain Fatty Acids	associated_with	compound	0.95
Brain	interacts_with	brain_region	0.95
Neurodegenerative Diseases	contributes_to	disease	0.95
Parkinson'S Disease	associated_with	disease	0.90
Neurological Disorders	associated_with	disease	0.90
Neurodegenerative Disorders	associated_with	disease	0.85
Brain	mediates	brain_region	0.85
Immune Dysregulation	contributes_to	process	0.85
Alzheimer's disease	implicated_in	disease	0.80
Parkinson's disease	implicated_in	disease	0.80
Neurodegeneration Progression	modulates	phenotype	0.75
Neurodegeneration	correlates_with	process	0.70
Neuroinflammation	regulates	process	0.70
Alzheimer'S Disease	associated_with	disease	0.70
Taurocholic acid	regulates	compound	0.70
gut-liver-brain axis	regulates	pathway	0.70
Neurodegeneration	modulates	process	0.70
CHRONIC INFLAMMATION	interacts_with	concept	0.50
Pain	interacts_with	disease	0.50
Telomere	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
CYTOKINE	regulates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
SYNUCLEIN	interacts_with	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
SYNUCLEIN	activates	concept	0.50

Incoming (244)

Source	Relation	Type	Str
SDA-2026-04-01-gap-20260401-225155	investigates	analysis	0.95
35248147	plays role in	paper	0.90
Circadian Rhythm	regulates	process	0.90
INFLAMMATION	associated_with	gene	0.90
Als	activates	disease	0.90
Als	therapeutic_target	disease	0.90
Inflammation	associated_with	disease	0.90
INFLAMMATION	activates	gene	0.90
Inflammation	activates	disease	0.90
Inflammation	therapeutic_target	disease	0.80
Cancer	therapeutic_target	disease	0.80
Alzheimer	associated_with	disease	0.80
INFLAMMATION	therapeutic_target	gene	0.80
Inflammation	regulates	disease	0.80
INFLAMMATION	regulates	gene	0.80
Parkinson	associated_with	disease	0.80
PARKINSON	associated_with	gene	0.80
ALZHEIMER	associated_with	gene	0.80
CANCER	therapeutic_target	gene	0.70
Als	causes	disease	0.70
Als	associated_with	disease	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
Neurodegeneration	activates	disease	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
Cardiovascular	therapeutic_target	disease	0.70
Aging	therapeutic_target	disease	0.70
NEURODEGENERATION	activates	gene	0.70
Neuroinflammation	activates	disease	0.70
NEUROINFLAMMATION	activates	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
MICROGLIA	activates	gene	0.70
Tumor	activates	disease	0.60
Colorectal Cancer	activates	disease	0.60
Cancer	activates	disease	0.60
SIRT1	regulates	gene	0.60
AMPK	regulates	gene	0.60
GENES	regulates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
Als	regulates	disease	0.60
Insulin Resistance	regulates	disease	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Parkinson	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming	0.907	neurodegeneration	What are the mechanisms by which gut mic
Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fu	0.540	neurodegeneration	How does gut microbiome dysbiosis contri
plasma LPS-binding protein separates causal from compensator	0.346	neurodegeneration	How does gut microbiome dysbiosis contri
TLR4 priming is the actionable driver in: How does gut micro	0.343	neurodegeneration	How does gut microbiome dysbiosis contri
microglial inflammasome tone defines the therapeutic window	0.341	neurodegeneration	How does gut microbiome dysbiosis contri

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Iron and the Intestinal Microbiome. [PMID:40603801]	Li H	Adv Exp Med Biol	2025
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP- [PMID:40958035]	Li Z, Sun X, Wang Y	Basic Res Cardiol	2025
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024
Joint-specific memory, resident memory T cells and the rolling window of opportu [PMID:38600215]	Chang MH, Fuhlbrigge RC, Nigrovic PA	Nat Rev Rheumatol	2024
Oral Microbiome: A Review of Its Impact on Oral and Systemic Health. [PMID:39338471]	Rajasekaran JJ, Krishnamurthy HK, Bosco	Microorganisms	2024
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662]	["Zhang Di", "Jing Bei", "Chen Zhen-Ni",	CNS neuroscience & therapeutic	2023
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081]	Park, Hwang, Lee, Jang, Jeong et al.	Frontiers in immunology	2023
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081]	Unknown	Frontiers in immunology	2023
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662]	["Zhang Di", "Jing Bei", "Chen Zhen-Ni",	CNS neuroscience & therapeutic	2023
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023
The role of Toll-like receptors and neuroinflammation in Parkinson's disease. [PMID:35668422]	["Heidari Arash", "Yazdanpanah Niloufar"	Journal of neuroinflammation	2022
Pyroptosis in acute pancreatitis and its therapeutic regulation. [PMID:35687256]	Al Mamun A, Suchi SA, Aziz MA	Apoptosis	2022
Microglia in multiple sclerosis: Protectors turn destroyers. [PMID:35882229]	Yong	Neuron	2022
Microglia in multiple sclerosis: Protectors turn destroyers. [PMID:35882229]	Unknown	Neuron	2022
The role of Toll-like receptors and neuroinflammation in Parkinson's disease. [PMID:35668422]	["Heidari Arash", "Yazdanpanah Niloufar"	Journal of neuroinflammation	2022
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory sign [PMID:33057840]	["Ciesielska A", "Matyjek M", "Kwiatkows	Cellular and molecular life sc	2021
Neuroinflammation in neurodegenerative disorders: the roles of microglia and ast [PMID:33239064]	Kwon, Koh	Translational neurodegeneratio	2021
AIM2 in regulatory T cells restrains autoimmune diseases. [PMID:33505023]	Chou WC, Guo Z, Guo H	Nature	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Gut Microbiome in their description or question text

No additional research found