Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POLG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
POLG2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.
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| Gene Symbol | POLG2 |
| Full Name | DNA Polymerase Gamma 2, Accessory Subunit |
| Chromosome | 17q24.1 |
| Function | encodes a protein of 380 amino acids with a molecular weight of approximately 55 kDa. |
| Primary Expression | all tissues with high energy requirements: |
| Molecular Weight | 55 kDa |
| Amino Acids | 380 aa |
| Pathways | Mitochondrial Function, Neurogenesis, Oxidative Stress, Stem Cell |
| UniProt ID | [O76071](https://www.uniprot.org/uniprot/O76071) |
| Ensembl ID | ENSG00000156500 |
| GeneCards | POLG2 |
| Human Protein Atlas | POLG2 |
| Associated Diseases | neurodegeneration |
| Interactions | BAX, DNA, MITOCHONDRIAL DNA, MITOCHONDRIAL DYSFUNCTION, MTDNA, NEURODEGENERATION |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
POLG2["POLG2"]
POLG["POLG"]
TFAM["TFAM"]
MTDNA["Mitochondrial DNA"]
MITO_FUNC["Mitochondrial Function"]
MITO_DYS["Mitochondrial Dysfunction"]
OXI_STRESS["Oxidative Stress"]
NEURODEGENERATION["Neurodegeneration"]
ALS["ALS"]
NEUROGENESIS["Neurogenesis"]
SLC25A4["SLC25A4"]
TK2["TK2"]
RRM2B["RRM2B"]
OPA1["OPA1"]
MFN2["MFN2"]
POLG2 -->|"forms complex with"| POLG
POLG2 -->|"regulates"| TFAM
POLG2 -->|"maintains"| MTDNA
POLG2 -->|"supports"| MITO_FUNC
POLG2 -->|"promotes"| NEUROGENESIS
POLG -->|"replicates"| MTDNA
TFAM -->|"regulates transcription"| MTDNA
MTDNA -->|"encodes proteins for"| MITO_FUNC
MITO_DYS -->|"leads to"| OXI_STRESS
MITO_DYS -->|"causes"| NEURODEGENERATION
OXI_STRESS -->|"contributes to"| NEURODEGENERATION
NEURODEGENERATION -->|"manifests as"| ALS
SLC25A4 -->|"supports"| MITO_FUNC
TK2 -->|"maintains"| MTDNA
RRM2B -->|"provides precursors for"| MTDNA
OPA1 -->|"regulates"| MITO_FUNC
MFN2 -->|"maintains"| MITO_FUNC
POLG2 -.->|"dysfunction leads to"| MITO_DYS
style POLG2 fill:#1a3a4a,stroke:#4fc3f7
style MITO_FUNC fill:#1b5e20
style NEUROGENESIS fill:#1b5e20
style NEURODEGENERATION fill:#ef5350
style ALS fill:#7d4200
style MITO_DYS fill:#ef5350
style OXI_STRESS fill:#ef5350
style POLG fill:#4a1a6b
style TFAM fill:#4a1a6b
style OPA1 fill:#4a1a6b
style MFN2 fill:#4a1a6b| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| Neurogenesis | activates | pathway | 0.60 |
| MITOCHONDRIAL DNA | activates | gene | 0.60 |
| Stem Cell | activates | pathway | 0.60 |
| MTDNA | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| SLC25A4 | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| genes-polg2 | linked_to | wiki_page | 1.00 |
| BAX | activates | gene | 0.60 |
| POLG | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning POLG2 in their description or question text
No additional research found