gene

APOC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

125Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

A gene referenced in 114 knowledge graph relationships. Key connections: regulates 19 bp APOE enhancer deletion (biomarker); regulates Alzheimer (disease); regulates Als (disease).

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🧬 Gene Info

Gene Symbol	APOC1
Full Name	Apolipoprotein C-I
Chromosome	19
Molecular Weight	~9 kDa
Amino Acids	79 aa
Exons	4
Pathways	Interaction
UniProt ID	P02654
NCBI Gene ID	341
Ensembl ID	ENSG00000130208
OMIM	107710
GeneCards	APOC1
Human Protein Atlas	APOC1
Associated Diseases	neurodegeneration
Interactions	ABCA1, ABCA2, APOA1, APOC2, APOC3, APOD
KG Connections	113 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APOC1 Gene — Apolipoprotein C-I

gene · 1786 words

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Pathway Diagram

flowchart TD
    A["APOC1"] --> B["Lipid Transport"]
    A --> C["APOE Regulation"]
    A --> D["LDL Receptor Binding"]
    B --> E["Neuronal Cholesterol Delivery"]
    C --> F["Amyloid-Beta Metabolism"]
    D --> E
    E --> G["Membrane Stability"]
    F --> H["Amyloid Plaque Formation"]
    G --> I["Synaptic Function"]
    F --> I
    C --> J["Triglyceride Metabolism"]

Outgoing (71)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APOC1	data_in	dataset_row	0.00
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
Als	degrades	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
ALZHEIMER	transports	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
LRP1	activates	gene	0.60
LRP8	activates	gene	0.60
C1QA	activates	gene	0.60
C1QC	activates	gene	0.60
CD14	activates	gene	0.60
CD163	activates	gene	0.60
CTSB	activates	gene	0.60
CTSL	activates	gene	0.60
FCGRT	activates	gene	0.60
TYROBP	activates	gene	0.60
APOE	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
MS4A6A	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
TOMM40	associated_with	gene	0.60
APOD	activates	gene	0.60
TFCP2	degrades	gene	0.60
App	degrades	protein	0.60
macrophages	expressed_in	cell_type	0.60
CH25H	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
ABCA2	activates	gene	0.60
TAU	regulates	gene	0.60
LDLR	activates	gene	0.60
APOC3	activates	gene	0.60
LRP1	transports	gene	0.60
SREBF1	transports	gene	0.60
APOC3	transports	gene	0.60

Incoming (54)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APOC1	data_in	dataset_row	0.00
19 bp APOE enhancer deletion	regulates	biomarker	0.85
APOA1	activates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	activates	gene	0.60
LIPA	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
LRP8	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APOD	activates	gene	0.60
TFCP2	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
ABCA7	associated_with	gene	0.60
APOD	transports	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	degrades	gene	0.60
CH25H	transports	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
APOA1	transports	gene	0.60
CYP46A1	transports	gene	0.60
SOAT1	transports	gene	0.60
APP	transports	gene	0.60
MAPT	transports	gene	0.60
ABCA2	transports	gene	0.60
PSEN1	transports	gene	0.60
TAU	transports	gene	0.60
APOC3	activates	gene	0.60
APP	degrades	gene	0.60
PSEN2	degrades	gene	0.60
MAPT	degrades	gene	0.60
SREBF1	degrades	gene	0.60
NCSTN	degrades	gene	0.60
PSEN1	degrades	gene	0.60
LDLR	activates	gene	0.60
CH25H	activates	gene	0.60
ABCA2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APOC1 in their description or question text

No additional research found