gene

BAG6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAG6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

9Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for BAG6 Gene

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🧬 Gene Info

Gene Symbol	BAG6
Full Name	BCL2-associated athanogene 6
Chromosome	6p21.1
Protein Type	Chaperone
Function	It operates in multiple cellular compartments including the cytosol, nucleus, and endoplasmic reticulum.
Molecular Weight	326 kDa
UniProt ID	Q9Y5W5
NCBI Gene ID	10127
Ensembl ID	ENSG00000138193
OMIM	607186
GeneCards	BAG6
Human Protein Atlas	BAG6
N-terminal Domain	Contains multiple LGL (Leu-Gly-Phe-Asn) sequence repeats that mediate client protein recognition
BAG Domain	C-terminal BAG domain (~50 aa) functions as the Hsp70 nucleotide exchange factor
UBA Domain	Ubiquitin-associated domain for recruiting ubiquitinated substrates
Associated Diseases	neurodegeneration
Interactions	ALS, UBQLN2
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BAG6 — AlphaFold Q9Y5W5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BAG6 Protein

protein · 749 words

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BAG6 Gene

gene · 745 words

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Pathway Diagram

flowchart TD
    N0["BAG6"]
    N1["Rs28732154"]
    N1 -->|"associated with"| N0
    N2["Cg27014438"]
    N2 -->|"regulates"| N0
    N3["ALS"]
    N3 -->|"associated with"| N0
    N0 -->|"associated with"| N2
    N0 -->|"biomarker for"| N3
    N4["oxidative stress response"]
    N0 -->|"participates in"| N4
    N5["epigenetic regulation"]
    N0 -->|"participates in"| N5
    N6["UBQLN2"]
    N0 -->|"activates"| N6

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N6 gene

Outgoing (9)

Target	Relation	Type	Str
Cg27014438	associated_with	biomarker	0.90
ALS	biomarker_for	disease	0.85
frontotemporal dementia	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
UBQLN2	inhibits	gene	0.60
UBQLN2	implicated_in	gene	0.60
UBQLN2	interacts_with	gene	0.60
UBQLN2	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
proteins-bag6-protein	describes	wiki_page	1.00
Rs28732154	associated_with	variant	0.85
Cg27014438	regulates	biomarker	0.80
ALS	associated_with	gene	0.60
ALS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAG6 in their description or question text

No additional research found