gene 3,256 words KG: UBQLN2
Contents

UBQLN2 — Ubiquilin 2

🧬 Gene Info
Gene SymbolUBQLN2
Full NameUbiquilin 2
Protein FamilyUbiquilin family
FunctionContains disease-causing mutations (P497H, P506T)
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight66 kDa
Amino Acids600 aa
Exons11
PathwaysProtein Degradation
UniProt IDQ9R0R5
GeneCardsUBQLN2
Human Protein AtlasUBQLN2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, frontotemporal dementia, FTLD, Ms
Interactions26S Proteasome, AGING, ALS, AMYOTROPHIC LATERAL SCLEROSIS, APP, ATXN2
KG Connections177 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (7)

Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (9)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Neurodegeneration
disease · KG edge: activates
FUS (Redirect)
redirect · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with

Knowledge Graph (12 edges)

UBQLN2 activates PROTEIN_DEGRADATION
UBQLN2 associated_with OPTN
UBQLN2 associated_with GAIN
UBQLN2 associated_with C9ORF72
UBQLN2 interacts_with HSP70
UBQLN2 interacts_with UNC5B
UBQLN2 associated_with UBIQUITIN
UBIQUITIN associated_with UBQLN2
UBQLN2 involved_in Protein Degradation
C9ORF72 inhibits UBQLN2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)