gene

RNASEH2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNASEH2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

RNASEH2B is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Tumor. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RNASEH2B
Full Name	Ribonuclease H2 Subunit B
Chromosome	13q14.13
Function	is a gene located on chromosome 13q14.
Primary Expression	Ubiquitously expressed; high expression in brain, testis, thyroid
Amino Acids	517 aa
Exons	14
Pathways	Immune Checkpoint
UniProt ID	Q9Y2Q9
NCBI Gene ID	79684
Ensembl ID	ENSG00000137713
OMIM	610296
GeneCards	RNASEH2B
Human Protein Atlas	RNASEH2B
Associated Diseases	Aicardi-Goutières Syndrome
Interactions	AND, ARID1A, CD8, DNA, IFN, STING
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RNASEH2B — AlphaFold Q9Y2Q9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RNASEH2B — Ribonuclease H2 Subunit B

gene · 738 words

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Pathway Diagram

graph TD
    RNASEH2B["RNASEH2B"]
    cytosolic_ssDNA["cytosolic ssDNA"]
    RNASEH2B -.->|"inhibits"| cytosolic_ssDNA
    Tumor{"Tumor"}
    RNASEH2B -->|"activates"| Tumor
    Cancer{"Cancer"}
    RNASEH2B -->|"activates"| Cancer
    Als{"Als"}
    RNASEH2B -->|"activates"| Als
    TREX1(["TREX1"])
    RNASEH2B -->|"activates"| TREX1
    CD8(["CD8"])
    RNASEH2B -->|"activates"| CD8
    ARID1A(["ARID1A"])
    ARID1A -->|"activates"| RNASEH2B
    AND(["AND"])
    AND -->|"activates"| RNASEH2B
    style RNASEH2B fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (10)

Target	Relation	Type	Str
cytosolic ssDNA	inhibits	phenotype	0.90
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Immune Checkpoint	activates	pathway	0.60
IFN	activates	gene	0.60
DNA	activates	gene	0.60
TREX1	activates	gene	0.60
CD8	activates	gene	0.60
STING	activates	gene	0.60

Incoming (5)

Source	Relation	Type	Str
ARID1A	activates	gene	0.60
CD8	activates	gene	0.60
TREX1	activates	gene	0.60
STING	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RNASEH2B in their description or question text

No additional research found