protein

INA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

30Hypotheses

0Analyses

1Outgoing

1Incoming

12Experiments

0Debates

Summary

Internexin (INA) has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.

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🔬 Protein Info

Gene Symbol	INA
Function	Internexin (INA) has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.
Subcellular Localization	to Cytoplasmic intermediate filament and plays a significant role in the pathoge
GeneCards	INA
Human Protein Atlas	INA
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INA["INA"]
    TPM2["TPM2"]
    TPM2 -->|"binds"| INA
    style INA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
NEURODEGENERATIVE DISEASES	involved_in	disease	0.90

Incoming (1)

Source	Relation	Type	Str
TPM2	binds	gene	0.80

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP Modulation Rather Than Cell Elimination	0.981	-	Senescent cell clearance as neurodegener
Selective Acid Sphingomyelinase Modulation Therapy	0.978	neurodegeneration	Lipid raft composition changes in synapt
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.940	-	What blood-brain barrier permeability ch
Closed-loop transcranial focused ultrasound targeting EC-II	0.940	Alzheimer's disease	Circuit-level neural dynamics in neurode
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph	0.879	neurodegeneration	What is the therapeutic window between i

Neutral Sphingomyelinase-2 Inhibition for Synaptic Protectio	0.844	neurodegeneration	Lipid raft composition changes in synapt
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Senescent Microglia Resolution via Maresins-Senolytics Combi	0.791	neurodegeneration	Neuroinflammation resolution mechanisms
G2019S primarily raises baseline LRRK2 kinase activity rathe	0.790	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle	0.772	neurodegeneration	How do different organelle-specific auto
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.735	-	What blood-brain barrier permeability ch
SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct	0.732	neurodegeneration	How do sphingomyelin/ceramide ratios spe
Selective Neutral Sphingomyelinase-2 Inhibition Therapy	0.731	neurodegeneration	Lipid raft composition changes in synapt
TFEB/TFE3 Parallel Activation Drives Coordinated Organelle C	0.727	neurodegeneration	How do different organelle-specific auto
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.724	neurodegeneration	How do the seven novel ALS genes functio
Astroglial Gap Junction Coordination via Connexin-43 Phospho	0.720	neurodegeneration	Perivascular spaces and glymphatic clear
VCP/p97 ATPase mutations impair extraction of ubiquitinated	0.720	neurodegeneration	What are the neuron-specific effects of
Retinal Vascular Microcirculation Rescue	0.718	neurodegeneration	Digital biomarkers and AI-driven early d
CSF YKL-40 as a Priming-Specific Chitinase Marker	0.714	biomarkers	What biomarkers can reliably detect micr
Creatine Kinase System Capacity as Neural Energy Reserve Bio	0.707	translational neuroscience	Which metabolic biomarkers can distingui
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
CHIP-mediated K63-linked ubiquitination redirects oligomeric	0.000	protein biochemistry	Do chaperones selectively recognize path
CHIP-mediated K63-linked ubiquitination promotes autophagoso	0.000	protein biochemistry	Do chaperones selectively recognize path
Aggregation-prone sequences trigger HSP90-dependent conforma	0.000	protein biochemistry	Do chaperones selectively recognize path
CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab	0.000	developmental neurobiology	Do perinatal immune challenges create pe
TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP-	0.000	ALS	What are the mechanisms by which microgl
TREM2-Mediated Microglial Regulation of Oligodendrocyte Prec	0.000	connectomics	Human connectome alterations in Alzheime
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.000	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (12)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
MAPK pathway inhibition by QTJD through butyrate mechanism	exploratory	Mycoplasma pneumoniae pneumoni	0.900	0.00	Mouse macrophages	proposed	N/A
nSMase2 Inhibitor DPTIP Rescues Synaptic Density in APPswe/PS1deltaE9	in_vivo	Alzheimer's disease	0.803	0.74	APPswe/PS1dE9 bigenic mice, 6-	proposed	$62,000
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000
Microglial Aging and Immune Memory in Neurodegeneration — Training the	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,960,000
Microglial Contributions to Huntington's Disease Pathogenesis	validation	Neuroinflammation	0.400	0.50	human	proposed	$2,960,000
Mixed Pathology Effects on Parkinson's Disease Progression and Treatme	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
NLRP3 Inflammasome Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the S [PMID:37738560]	Justice JN, Leng XI, LeBrasseur NK, Tchk	J Gerontol A Biol Sci Med Sci	2024	1
Sex differences in autophagy-mediated diseases: toward precision medicine. [PMID:32264724]	Shang D, Wang L, Klionsky DJ, Cheng H, Z	Autophagy	2021	1
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populatio [PMID:33144684]	He D, Wang D, Lu P, Yang N, Xue Z, Zhu X	Oncogene	2021	1
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells [PMID:26657143]	Chang J, Wang Y, Shao L, Laberge RM, Dem	Nat Med	2016	1
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. [PMID:25754370]	Zhu Y, Tchkonia T, Pirtskhalava T, Gower	Aging Cell	2015	1
Coenzyme Q10 Supplementation Modulates Hepatic Lipidomic Alterations and Attenua [PMID:41754105]	Go Y, Joung H, Han SY, Chung J	Nutrients	2026	0
SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immuno [PMID:41795144]	Xu Y, Liu X, Xu B, Li Q, Zhang L, Li C,	CNS neuroscience & therapeutic	2026	0
Senolytic elimination of therapy-induced senescent cells by ABT-263 improves che [PMID:41423036]	Zhang D, Zhu J, Zou R, Zhang H, Yu BP, L	Biochemical pharmacology	2026	0
Comprehensive assessment of the genomic stability of human induced pluripotent s [PMID:41877289]	Zhang K, Na T, Jia C, Yuan X, Guo M, Yan	Stem cell research & therapy	2026	0
Characterization of the Direct and Indirect Inhibition of Apoptosis by Full-Leng [PMID:41589352]	Elsner C, Epasto LM, Cieren A, Gendreizi	Chembiochem : a European journ	2026	0
Exploring the key molecular mechanisms and immune microenvironment of oxidative [PMID:41591671]	Cai Z, Li J, Li T, Peng Q	Discover oncology	2026	0
Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Ant [PMID:41824764]	Liu H, Aili A, Kuang Z, Cao L, Li Z, Sha	Advanced science (Weinheim, Ba	2026	0
Suspected Niemann-Pick disease type B with sea-blue histiocytosis after splenect [PMID:41791926]	Liu W, Qin L, Wang G	Journal of clinical lipidology	2026	0
Olipudase alfa treatment for pediatric acid sphingomyelinase deficiency in Egypt [PMID:41716780]	Arafa NA, Mahfouz A, Anwar S, Marzouk I	Molecular genetics and metabol	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014]	Chestnykh D, Mühle C, Schumacher F, Kali	Mol Psychiatry	2025	0
Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679]	Boyle NR, Fox SN, Tadepalli AS, Seyfried	Neurobiol Dis	2025	0
Navitoclax acts synergistically with irradiation to induce apoptosis in preclini [PMID:41430412]	Vardon A, Haston S, Hamdi H, Cooksley G,	Scientific reports	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014]	Chestnykh D, Mühle C, Schumacher F, Kali	Molecular psychiatry	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INA in their description or question text

Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurodegenerati

Score: 0.844 · neurodegeneration · 2026-04-07

## Mechanistic Overview Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurodegeneration starts from t

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

Score: 0.801 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Diseas

Senescent Microglia Resolution via Maresins-Senolytics Combination

Score: 0.791 · neurodegeneration · 2026-04-02

## Mechanistic Overview Senescent Microglia Resolution via Maresins-Senolytics Combination starts from the claim that mo

G2019S primarily raises baseline LRRK2 kinase activity rather than amplifying ly

Score: 0.790 · neurodegeneration · 2026-04-24

The most supported model is that pathogenic G2019S shifts the basal catalytic set-point upward, producing higher baselin

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy

Score: 0.772 · neurodegeneration · 2026-04-21

## Mechanistic Overview TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy starts from the claim that

C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli

Score: 0.747 · neurodegeneration · 2026-04-15

**Molecular Mechanism and Rationale** The complement system's classical pathway, initiated by C1q complex formation, re

Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Blood as an Early Indi

Score: 0.735 · unknown disease · 2026-04-26

Elevated MMP-9/TIMP-1 ratio reflects net proteolytic activity against the BBB, causing degradation of tight junction pro

SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regula

Score: 0.732 · neurodegeneration · 2026-04-16

**Molecular Mechanism and Rationale** The molecular foundation for SMPD1 inhibition in Alzheimer's disease centers on t

Selective Neutral Sphingomyelinase-2 Inhibition Therapy

Score: 0.731 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The pathophysiological foundation of this therapeutic approach centers on the dys

TFEB/TFE3 Parallel Activation Drives Coordinated Organelle Clearance via CLEAR N

Score: 0.727 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The transcription factor EB (TFEB) and transcription factor E3 (TFE3) represent m

TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I

Score: 0.724 · neurodegeneration · 2026-04-13

**Molecular Mechanism and Rationale** The molecular cascade underlying TBK1 loss-of-function-mediated synapse eliminati

Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation

Score: 0.720 · neurodegeneration · 2026-04-02

## Mechanistic Overview Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation starts from the

VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates

Score: 0.720 · neurodegeneration · 2026-04-21

## Mechanistic Overview VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates, causing protea

Retinal Vascular Microcirculation Rescue

Score: 0.718 · neurodegeneration · 2026-04-02

## Mechanistic Overview Retinal Vascular Microcirculation Rescue starts from the claim that modulating PDGFRB/ANGPT1 wit

INA