protein

MUNC18-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MUNC18-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

1Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for Munc18-1 Protein

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🔬 Protein Info

Gene Symbol	MUNC18
Aliases	STXBP1
Chromosome	9q34.3
Protein Family	Sec1/Munc18 (SM) family
Function	regulating synaptic vesicle release
Subcellular Localization	Presynaptic terminals, cytosol
Molecular Weight	67 kDa
Amino Acids	594 aa
Exons	20
UniProt ID	Q9Y2L9
GeneCards	MUNC18
Human Protein Atlas	MUNC18
Associated Diseases	Alzheimer's disease
Interactions	HSC70, Proteins, SNAP-25, STXBP1
KG Connections	4 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MUNC18-1 — AlphaFold Q9Y2L9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    MUNC18_1(["MUNC18-1"])
    Proteins(["Proteins"])
    STXBP1["STXBP1"]
    SNAP_25(["SNAP-25"])
    HSC70(["HSC70"])

    MUNC18_1 -->|"interacts with"| Proteins
    STXBP1 -->|"interacts with"| MUNC18_1
    SNAP_25 -->|"interacts with"| MUNC18_1
    HSC70 -->|"interacts with"| MUNC18_1

    style MUNC18_1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Proteins fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style STXBP1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style SNAP_25 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style HSC70 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff

Outgoing (1)

Target	Relation	Type	Str
Proteins	interacts_with	protein	0.50

Incoming (3)

Source	Relation	Type	Str
STXBP1	interacts_with	gene	0.50
SNAP-25	interacts_with	protein	0.50
HSC70	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MUNC18-1 in their description or question text

No additional research found