| Gene Symbol | STXBP1 |
| Full Name | Munc18-1 |
| Protein Type | Protein |
| Function | is a neuronal protein essential for synaptic vesicle release and neurotransmitter secretion. |
| Primary Expression | non-neuronal tissues, important for immune function |
| Molecular Weight | 66 kDa |
| Amino Acids | 594 aa |
| UniProt ID | Search UniProt |
| GeneCards | STXBP1 |
| Human Protein Atlas | STXBP1 |
| Domain 1a | N-terminal region that binds to the N-terminal peptide of syntaxin-1 |
| Domain 1b | Central region involved in regulatory interactions |
| Domain 2/3 | C-terminal region that forms a tight complex with full-length syntaxin-1 |
| Munc18-1 (STXBP1) | Neuron-specific isoform, most abundant in the brain |
| Munc18-2 (STXBP2) | Expressed in non-neuronal tissues, important for immune function |
| Associated Diseases | ALS, neurodegeneration |
| Interactions | DNAJC5, ERK, GENES, HSC70, MUNC18-1, NEURODEGENERATION |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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