Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | C6 |
| Full Name | Complement Component 6 |
| Chromosome | 5p13.1 |
| Protein Family | Complement system (terminal pathway) |
| Function | C6 functions exclusively in the terminal complement pathway[@structure2015][@complement2018]: |
| Subcellular Localization | Plasma, cell membrane |
| Molecular Weight | 120 kDa |
| Amino Acids | 922 aa |
| UniProt ID | P13671 |
| GeneCards | C6 |
| Human Protein Atlas | C6 |
| N-terminal domain | Contains cysteine-rich repeats (MCP/CD46-like) |
| Thrombospondin type I repeats | Protein-protein interaction motifs |
| C-terminal domain | Critical for complex formation with C5b-7 |
| Disulfide bonds | Stabilize protein structure |
| Associated Diseases | neurodegeneration |
| Interactions | C3, CYP46A1, CYP7B1, SARM1 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["C6"]
N1["C3"]
N1 -->|"activates"| N0
N2["C2"]
N2 -->|"expressed in"| N0
N3["CYP46A1"]
N0 -->|"activates"| N3
N4["CYP7B1"]
N0 -->|"activates"| N4
N5["PSP"]
N0 -->|"regulates"| N5
N6["TG2"]
N0 -->|"regulates"| N6
N7["blood-brain barrier"]
N0 -->|"participates in"| N7
N8["SARM1"]
N0 -->|"activates"| N8
N9["neuroinflammation"]
N0 -->|"regulates"| N9
N10["autophagy pathway"]
N0 -->|"participates in"| N10
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classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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class N0 gene
class N1 gene
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 pathway
class N8 gene
class N9 disease
class N10 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| TG2 | regulates | gene | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| SARM1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| PSP | regulates | gene | 0.60 |
| neuroinflammation | regulates | disease | 0.60 |
| CYP46A1 | activates | gene | 0.60 |
| CYP7B1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism | 0.682 | neurodegeneration | Do SCFAs directly modulate α-synuclein a |
| HDAC6 Selective Inhibition to Restore Acetylation Balance an | 0.643 | structural biology | What is the atomic-resolution structure |
| Brain-Ester Prodrug Strategy for CNS-Selective HDAC6 Inhibit | 0.570 | pharmacology | How can CNS-selective HDAC/DNMT inhibito |
| HDAC6 Inhibition for Dual Restoration of Microtubule Stabili | 0.484 | neurodegeneration | Which tau PTMs are both disease-specific |
| HDAC6 Inhibitor Therapy for Pan-Neurodegenerative Protein Ho | 0.450 | neurodegeneration | Comparative epigenetic signatures across |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning C6 in their description or question text
No additional research found