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mechanism 1,124 words KG: SARM1
Contents

sarm1-programmed-axon-degeneration

⚙ Mechanism Info
NameSARM1
Key Genes/ProteinsALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, AUTOPHAGY
Related DiseasesAging, Als, Alzheimer, Alzheimer's disease, Alzheimer's Disease
Related PathwaysApoptosis, Autophagy
Linked Hypotheses2 hypotheses

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Wikipedia

Related Hypotheses (6)

Netrin-1 Gradient Restoration
Score: 0.59...
Score: 0.68Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (26)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

blarcamesine-axon
clinical_trial · KG edge: activatesNeuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: activatesNeurodegeneration
disease · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: activatesAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

SARM1 activates axonal degeneration
SARM1 regulates neuroinflammation
SARM1 associated_with Alzheimer's disease
SARM1 expressed_in hippocampal neurons
TNF inhibits SARM1
NAD activates SARM1
APOPTOSIS activates SARM1
AXON activates SARM1
BAX activates SARM1
SARM1 activates DLK

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