Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Palmitoylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| RIPK1 | activates | protein | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 | 0.861 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Palmitoylation-Targeted BACE1 Trafficking Disruptors | 0.693 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Synaptic plasticity and protein expression analysis in mPFC | exploratory | insomnia-anxiety comorbidity | 0.850 | 0.00 | mPFC brain slices from PCPA-tr | proposed | N/A |
| ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Blocking palmitoyl-transferase activity reduces BACE1 membrane localization and [PMID:23395894] | Unknown | Molecular Neurodegeneration | 0 | |
| Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820] | Nishioka K, Ikezaki M, Iwahashi N, Araka | Life Sci Alliance | 2026 | 0 |
| An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149] | Fang W, Zhao J, Li L, Wang Y, Xu ZP et a | Mater Today Bio | 2026 | 0 |
| Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110] | Natale Francesca; Dellaria Alice; Nifo S | Alzheimer's research & the | 2026 | 0 |
| Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874] | Xiao S, Han Y, Yan J, Wu L, Lin H et al. | Int Immunopharmacol | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in [PMID:41482106] | Kaur A, Singh S, Singh M, Silakari P, Ma | Experimental neurology | 2026 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J et a | CNS Neurosci Ther | 2025 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J, Yi | CNS neuroscience & therapeutic | 2025 | 0 |
| Proposed Therapeutic Strategy to Combat Alzheimer's Disease by Targeting Beta an [PMID:40491367] | ["Kumar D", "Anand P", "Singh S"] | Current Alzheimer research | 2025 | 0 |
| BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitabili [PMID:40015276] | Bi D, Bao H, Yang X, Wu Z, Yang X, Xu G, | Neuron | 2025 | 0 |
| Unmasking BACE1 in aging and age-related diseases. [PMID:36509631] | ["Bao H", "Shen Y"] | Trends in molecular medicine | 2023 | 0 |
| BACE1: More than just a β-secretase. [PMID:35119166] | ["Taylor H", "Przemylska L", "Clavane E" | Obesity reviews : an official | 2022 | 0 |
| The β-Secretase BACE1 in Alzheimer's Disease. [PMID:32223911] | ["Hampel H", "Vassar R", "De Strooper B" | Biological psychiatry | 2021 | 0 |
| Early elevation of BACE1 in dementia. [PMID:34845111] | Carlo Cervellati; Giuseppe Valacchi; Gio | Aging | 2021 | 0 |
| Identification of tell-tale patterns in the 3' non-coding region of hantaviruses [PMID:29559625] | Sathish Sankar; Jayanta Borkakoti; Mages | Emerging microbes & infect | 2018 | 0 |
| Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Witho [PMID:28360087] | ["Denimal D", "Monier S", "Brindisi M", | Arteriosclerosis, thrombosis, | 2017 | 0 |
| Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release [PMID:27170175] | ["Zimnicka A", "Husain Y", "Shajahan A", | Molecular biology of the cell | 2016 | 0 |
| Quantitative assessment of the stent/scaffold strut embedment analysis by optica [PMID:26898315] | ["Sotomi Y", "Tateishi H", "Suwannasom P | The international journal of c | 2016 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Palmitoylation in their description or question text
No additional research found