concept

PURINERGIC SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PURINERGIC SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

2Hypotheses

1Analyses

22Outgoing

50Incoming

4Experiments

1Debates

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💡 Concept Info

Name	PURINERGIC SIGNALING
Related Diseases	DIABETES

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Purinergic Signaling in Neurodegeneration

mechanism · 1382 words

→

Pathway Diagram

graph TD
    PURINERGIC_SIGNALING["PURINERGIC SIGNALING"]
    PURINERGIC_SIGNALING -->|"involved_in"| Neuro_immune_Cell_Functions["Neuro-immune Cell Functions"]
    PURINERGIC_SIGNALING -->|"correlates_with"| Coagulation["Coagulation"]
    PURINERGIC_SIGNALING -->|"expressed in"| Leukocyte["Leukocyte"]
    PURINERGIC_SIGNALING -->|"regulates"| PANCREATIC_B_CELL_FUNCTION["PANCREATIC B-CELL FUNCTION"]
    PURINERGIC_SIGNALING -->|"regulates"| GLUCOSE_REGULATION["GLUCOSE REGULATION"]
    PURINERGIC_SIGNALING -.protects against.-> SYNAPSE["SYNAPSE"]
    ATP["ATP"] -->|"involved_in"| PURINERGIC_SIGNALING
    NAD_["NAD+"] -->|"involved_in"| PURINERGIC_SIGNALING
    ADP["ADP"] -->|"activates"| PURINERGIC_SIGNALING
    Adenosine["Adenosine"] -->|"activates"| PURINERGIC_SIGNALING
    P2RY1["P2RY1"] -->|"participates in"| PURINERGIC_SIGNALING
    P2RX7["P2RX7"] -->|"participates in"| PURINERGIC_SIGNALING
    B_CELLS["B CELLS"] -->|"regulates"| PURINERGIC_SIGNALING

Outgoing (22)

Target	Relation	Type	Str
Neuro-immune Cell Functions	involved_in	process	0.95
Huntington's Disease	associated_with	disease	0.90
Coagulation	correlates_with	process	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Neuro-Immune Cell Functions	regulates	process	0.90
Immune Cell Activation	regulates	process	0.90
Alzheimer's Disease	associated_with	disease	0.90
Multiple Sclerosis	associated_with	disease	0.90
Parkinson's Disease	associated_with	disease	0.90
Leukocyte	expressed_in	cell_type	0.85
PANCREATIC B-CELL FUNCTION	regulates	entity	0.85
GLUCOSE REGULATION	regulates	entity	0.85
pancreatic beta cell function	regulates	cell_type	0.82
Pancreatic Beta-Cell Function	regulates	process	0.80
microglia	active_in	cell_type	0.80
coagulation	associated_with	pathway	0.80
Glucose Regulation	associated_with	process	0.75
ASTROCYTES	mediates	cell_type	0.75
pyroptosis	crosstalk_with	pathway	0.60
astrocytes	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
macrophages	active_in	cell_type	0.60

Incoming (59)

Source	Relation	Type	Str
P2RX7	involved_in	gene	0.90
P2RY12	involved_in	gene	0.90
ENTPD1	regulates	gene	0.85
CD38	regulates	gene	0.85
ATP	participates_in	gene	0.85
microglia	active_in	cell_type	0.85
ADP	activates	compound	0.85
Adenosine	activates	compound	0.85
Extracellular Nucleotide Receptors	mediates	receptor	0.80
purinergic receptor	activates	receptor	0.80
P2RY12	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
Alzheimer's disease	involves	disease	0.75
neurons	active_in	cell_type	0.75
P2Y12	participates_in	gene	0.75
DAM microglia	active_in	cell_type	0.75
P2X7	participates_in	gene	0.75
neurodegeneration	involves	disease	0.75
NLRP3	participates_in	gene	0.65
Parkinson's disease	involves	disease	0.65
GFAP	participates_in	gene	0.65
neuroinflammation	involves	disease	0.65
tauopathy	involves	disease	0.65
depression	involves	disease	0.60
GABA	participates_in	gene	0.60
diabetes	involves	disease	0.60
TLR	participates_in	gene	0.55
PI3K	participates_in	gene	0.55
CD47	participates_in	gene	0.55
PSP	participates_in	gene	0.55
ASC	participates_in	gene	0.55
TMEM119	participates_in	gene	0.55
AQP4	participates_in	gene	0.55
AQP1	participates_in	gene	0.55
IKK	participates_in	gene	0.55
CD39	participates_in	gene	0.55
ADORA2A	participates_in	gene	0.55
PANX1	participates_in	gene	0.55
RNA	participates_in	gene	0.55
stem cells	active_in	cell_type	0.55
frontotemporal dementia	involves	disease	0.55
AMPK	participates_in	gene	0.55
P2RY1	participates_in	gene	0.55
P2RX7	participates_in	gene	0.55
C3	participates_in	gene	0.55
BDNF	participates_in	gene	0.55
GDNF	participates_in	gene	0.55
aducanumab	modulates	drug	0.55
lecanemab	modulates	drug	0.55
GRN	participates_in	gene	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Purinergic Signaling Polarization Control	0.713	neurodegeneration	Astrocyte reactivity subtypes in neurode
P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to S	0.423	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (1)

Scientific analyses that reference this entity

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - GPR32 knockout in microglia should worsen neuroinflammation if	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$240,000
Endocannabinoid System Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Purinergic Signaling Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Purinergic signaling elements are correlated with coagulation players in periphe [PMID:35091759]	Schultz IC, Bertoni APS, Wink MR	J Mol Med (Berl)	2022	1
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PMID:35386996]	Thompson RJ, Sayers I, Kuokkanen K, Hall	Front Allergy	2021	1
Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in m [PMID:25719930]	Todd JN, Poon W, Lyssenko V, Groop L, Ni	J Clin Endocrinol Metab	2015	1
CSF ATP levels correlate with Alzheimer's disease severity and predict progressi [PMID:synthetic_4]	Unknown	JAMA Neurol	2024	0
Astrocyte phenotype switching controlled by purinergic receptor balance regulate [PMID:synthetic_1]	Unknown	Nature Neuroscience	2023	0
P2Y1 agonist enhances astrocyte-mediated neuroprotection via BDNF upregulation [PMID:synthetic_3]	Unknown	Glia	2023	0
Astrocyte phenotype heterogeneity may not fit simple A1/A2 binary classification [PMID:synthetic_8]	Unknown	Cell	2023	0
P2X7 antagonists failed to show efficacy in depression trials despite target eng [PMID:synthetic_6]	Unknown	Mol Psychiatry	2022	0
P2X7 antagonist reduces amyloid pathology and preserves cognition in APP/PS1 mic [PMID:synthetic_2]	Unknown	Neurobiol Dis	2022	0
JNJ-47965567 P2X7 antagonist shows CNS penetration and safety in Phase 2 trial [PMID:synthetic_5]	Unknown	Lancet Psychiatry	2021	0
P2Y1 agonists cause platelet activation and thrombotic risk in cardiovascular mo [PMID:synthetic_7]	Unknown	Thromb Haemost	2020	0
Functional coordination and HuR-mediated regulation of mRNA stability during T c [PMID:26490963]	["Blackinton J", "Keene J"]	Nucleic acids research	2016	0
Characterization of a novel function-blocking antibody targeted against the plat [PMID:25593131]	["Karim Z", "Vemana H", "Alshbool F", "L	Arteriosclerosis, thrombosis,	2015	0
Dysregulation of leukocyte gene expression in women with medication-refractory d [PMID:24143878]	Iacob E, Light KC, Tadler SC, Weeks HR,	BMC psychiatry	2013	0
Evidence of HPV subtypes linked with cervical cancer in Nepal. [PMID:28615609]	["Bhusal C", "Manandhar S", "Singh M", "	WHO South-East Asia journal of	2012	0
Purinergic receptors are part of a functional signaling system for proliferation [PMID:12787128]	Greig AV, Linge C, Terenghi G, McGrouthe	The Journal of investigative d	2003	0

Debates (1)

Multi-agent debates referencing this entity

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning PURINERGIC SIGNALING in their description or question text

No additional research found