Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about astrocyte-microglia cross-talk: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| purinergic signaling | modulates | pathway | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene | 0.708 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen | 0.680 | neurodegeneration | TREM2 in Alzheimer's Disease: Mechanisms |
| TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene | 0.642 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene | 0.625 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinfla | 0.380 | neurodegeneration | Spatial Transcriptomics Analysis of Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.861
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREM2 Agonist Antibody Rescue of Astrocyte-Microglia Signalling in 5xF | in_vivo | Alzheimer's disease | 0.794 | 0.72 | 5xFAD transgenic mice (n=15/gr | proposed | $85,000 |
| TREM2 R47H iPSC Co-culture Screen for A1 Astrocyte Polarisation Rescue | in_vitro | Alzheimer's disease | 0.788 | 0.75 | Human iPSC-derived astrocytes | proposed | $52,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are in [PMID:41513633] | He S, Mittra N, Bao H, Bhattacharjee A, | Nat Commun | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | The Neuroscientist : a review | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pa [PMID:38255891] | Batista André F; Khan Khyrul A; Pap | International journal of molec | 2024 | 0 |
| The role of microglial TREM2 in development: A path toward neurodegeneration? [PMID:38837837] | ["Matteoli Michela"] | Glia | 2024 | 0 |
| TREM2 receptor protects against complement-mediated synaptic loss by binding to [PMID:37442133] | Zhong L, Sheng X, Wang W, Li Y, Zhuo R, | Immunity | 2023 | 0 |
| Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurod [PMID:33603230] | Dong Y, D'Mello C, Pinsky W, Lozinski BM | Nature neuroscience | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's [PMID:32296418] | Hampel H, Caraci F, Cuello AC, Caruso G, | Frontiers in immunology | 2020 | 0 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of [PMID:32711525] | ["Taylor Xavier", "Cisternas Pablo", "Yo | Journal of neuroinflammation | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
closed · Rounds: 4 · Score: 0.64 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.92 · 2026-04-26
Hypotheses and analyses mentioning astrocyte-microglia cross-talk in their description or question text
No additional research found