| Gene Symbol | PLG |
| Full Name | Plasminogen |
| Chromosome | 6q26 |
| Function | tPA-mediated activation: Tissue plasminogen activator (tPA) activates plasminogen preferentially in the presence of fibrin, making it important for clot-specific fibrinolysis. |
| Primary Expression | neurons and can be released in response to neuronal activity |
| Amino Acids | 810 aa |
| UniProt ID | [P00747](https://www.uniprot.org/uniprot/P00747) |
| Ensembl ID | ENSG00000122194 |
| GeneCards | PLG |
| Human Protein Atlas | PLG |
| PAI-1 (SERPINE1) | Primary inhibitor of tPA and uPA |
| PAI-2 (SERPINE2) | Alternative inhibitor expressed in brain |
| Alpha-2 antiplasmin | Direct inhibitor of plasmin |
| Associated Diseases | Als, Inflammation, Ms |
| Interactions | NFKB1, TGFB1 |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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