gene

GOT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GOT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

15Outgoing

8Incoming

0Experiments

0Debates

Summary

GOT2 encodes mitochondrial aspartate aminotransferase, a key enzyme in the malate-aspartate shuttle with roles in neurodegeneration

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GOT2
Full Name	Glutamic-Oxaloacetic Transaminase 2
Chromosome	16q21
Protein Type	Enzyme
Function	### Enzymatic Activity
Subcellular Localization	the mitochondrial matrix. It catalyzes:
Molecular Weight	45 kDa
Pathways	Mitophagy
UniProt ID	[P07148](https://www.uniprot.org/uniprot/P07148)
Ensembl ID	ENSG00000125107
GeneCards	GOT2
Human Protein Atlas	GOT2
Amino group transfer	Nitrogen trafficking between amino acids
Carbon skeleton metabolism	Linking glycolysis to the TCA cycle
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	MITOCHONDRIA, Ras
KG Connections	23 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GOT2 Gene

gene · 1301 words

→

Pathway Diagram

graph TD
    GOT2["GOT2"]
    Cardiac{"Cardiac"}
    GOT2 -->|"regulates"| Cardiac
    Ms{"Ms"}
    GOT2 -->|"regulates"| Ms
    Cardiovascular{"Cardiovascular"}
    GOT2 -->|"regulates"| Cardiovascular
    Mitophagy(["Mitophagy"])
    GOT2 -->|"regulates"| Mitophagy
    neurodegeneration["neurodegeneration"]
    GOT2 -->|"implicated in"| neurodegeneration
    P4HB["P4HB"]
    P4HB -->|"regulates"| GOT2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| GOT2
    PTGS2["PTGS2"]
    PTGS2 -->|"regulates"| GOT2
    GRB2["GRB2"]
    GRB2 -->|"regulates"| GOT2
    NDP52["NDP52"]
    NDP52 -->|"regulates"| GOT2
    GSK3B["GSK3B"]
    GSK3B -->|"regulates"| GOT2
    style GOT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
ALS	biomarker_for	disease	0.65
Cardiac	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Als	biomarker_for	disease	0.65
FCGRT	biomarker_for	gene	0.60
NDP52	regulates	gene	0.60
PTGS2	regulates	gene	0.60
Rb	regulates	protein	0.60
MITOCHONDRIA	inhibits	gene	0.60
Ras	inhibits	protein	0.60
Rb	biomarker_for	protein	0.60
Mitophagy	regulates	pathway	0.60
GENES	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60

Incoming (8)

Source	Relation	Type	Str
P4HB	regulates	gene	0.60
PTGS2	regulates	gene	0.60
GRB2	regulates	gene	0.60
NDP52	regulates	gene	0.60
GSK3B	regulates	gene	0.60
FCGRT	biomarker_for	gene	0.60
MITOPHAGY	regulates	gene	0.60
GENES	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GOT2 in their description or question text

No additional research found