Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CFL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CFL1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, implicated in. Associated with Als, Ataxia, Cancer. Connected to 14 entities in the SciDEX knowledge graph.
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| Gene Symbol | CFL1 |
| Function | Cofilin 1 is a small actin-binding protein (19 kDa) that promotes the disassembly and reassembly of actin filaments. |
| Molecular Weight | 19 kDa |
| Amino Acids | 166 aa |
| Pathways | Apoptosis |
| Ensembl ID | ENSG00000132716 |
| GeneCards | CFL1 |
| Human Protein Atlas | CFL1 |
| Actin Filament Turnover | Cofilin binds to aged or ADP-actin subunits within filaments, promoting their depolymerization and enabling rapid actin dynamics essential for cellular motility, endocytosis, and cytokinesis. |
| Neuronal Morphogenesis | In neurons, cofilin regulates actin dynamics in growth cones, dendritic spines, and axonal branches, influencing neuronal migration, axon guidance, and synapse formation. |
| Axonal Transport | The actin cytoskeleton provides tracks for myosin-based transport in regions where microtubules are sparse. Cofilin regulates this process in axons and dendrites. |
| Nuclear Functions | Cofilin can translocate to the nucleus where it may regulate gene expression and chromatin remodeling. |
| Associated Diseases | Als |
| Interactions | EFHD2 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CFL1["CFL1"]
Tumor{"Tumor"}
CFL1 -->|"expressed in"| Tumor
Senescence{"Senescence"}
CFL1 -->|"expressed in"| Senescence
Als{"Als"}
CFL1 -->|"associated with"| Als
Cancer{"Cancer"}
CFL1 -->|"expressed in"| Cancer
Ataxia{"Ataxia"}
CFL1 -->|"expressed in"| Ataxia
ATM["ATM"]
CFL1 -->|"expressed in"| ATM
Apoptosis(["Apoptosis"])
CFL1 -->|"expressed in"| Apoptosis
neurodegeneration["neurodegeneration"]
CFL1 -->|"implicated in"| neurodegeneration
LGALS1["LGALS1"]
LGALS1 -->|"associated with"| CFL1
P4HB["P4HB"]
P4HB -->|"associated with"| CFL1
MT2A["MT2A"]
MT2A -->|"associated with"| CFL1
CANCER["CANCER"]
CANCER -->|"expressed in"| CFL1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| CFL1
TERT["TERT"]
TERT -->|"expressed in"| CFL1
style CFL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Tnfr1 Internalization | mediates | process | 0.85 |
| Tumor | expressed_in | disease | 0.65 |
| Senescence | expressed_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Ataxia | expressed_in | disease | 0.65 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Alzheimer's disease | regulates | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| ATM | expressed_in | gene | 0.60 |
| P2RY12 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CFL1 in their description or question text
No additional research found