Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR120: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GPR120 |
| Key Genes/Proteins | CMKLR1, CXCL11, CXCL12, GPR109A, NLRP3 |
| Related Diseases | epilepsy, neuroinflammation, OBESITY |
| Related Pathways | apoptosis pathway, NF-kB signaling, pyroptosis |
graph TD
GPR120[GPR120]
GPR120 -->|modulates| Neuroinflammation[Neuroinflammation]
GPR120 -->|downregulates| NLRP3[NLRP3]
GPR120 -.protects against.-> Temporal_Lobe_Epilepsy[Temporal Lobe Epilepsy]
GPR120 -->|inhibits| Neuronal_Death[Neuronal Death]
GPR120 -->|causes| OBESITY[OBESITY]
GPR120 -->|activates| epilepsy[epilepsy]| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | modulates | process | 0.95 |
| NLRP3 | regulates | protein | 0.90 |
| Temporal Lobe Epilepsy | protects_against | disease | 0.88 |
| Neuronal Death | inhibits | process | 0.87 |
| OBESITY | causes | disease | 0.65 |
| pyroptosis | participates_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| epilepsy | activates | disease | 0.60 |
| epilepsy | inhibits | disease | 0.60 |
| epilepsy | regulates | disease | 0.60 |
| NLRP3 | inhibits | gene | 0.60 |
| neuroinflammation | regulates | disease | 0.60 |
| neuroinflammation | inhibits | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPR120 in their description or question text
No additional research found