| Gene Symbol | FTO |
| Aliases | Fat Mass and Obesity-Associated Protein |
| Function | FTO (Fat Mass and Obesity-Associated Protein), also known as ALKBH9, is a 505-amino acid nuclear and cytoplasmic protein that functions as an N6-methyladenosine (m6A) demethylase. |
| Subcellular Localization | </strong> Nucleus, cytoplasm</div> <div class="infobox-row"><strong>Protein Fa |
| Molecular Weight | 58.6 kDa |
| Amino Acids | 505 aa |
| Pathways | autophagy, adipogenesis, IGF1 signaling, Lipid Metabolism, Oxidative Stress |
| GeneCards | FTO |
| Human Protein Atlas | FTO |
| m6A Demethylation | FTO is the first discovered m6A demethylase, removing m6A modifications from mRNA and regulating RNA stability, translation, and splicing |
| Energy Balance | FTO in the hypothalamus regulates food intake and energy expenditure; FTO variants are associated with obesity risk |
| Neuronal Development | m6A demethylation regulates the timing of neuronal differentiation during development |
| Synaptic Plasticity | FTO activity affects synaptic protein synthesis and plasticity; FTO knockdown impairs memory formation |
| Stress Response | FTO expression is regulated by cellular stress, and its demethylase activity modulates stress response gene expression |
| Small Molecule Inhibitors | Rhein, FB23-2, and other FTO inhibitors are being developed for cancer and potentially for neurodegeneration |
| Associated Diseases | Alzheimer's disease, Fat Mass And Obesity, Obesity |
| Known Drugs/Compounds | FB23, N6-Methyladenosine |
| Interactions | CERS6, DNA, IGF1, PARP1, RNA, UCP2 |
| KG Connections | 83 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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