| Gene Symbol | NEUREXIN1 |
| Function | - Neurotransmitter release: Regulates vesicle docking, priming, and fusion |
| Subcellular Localization | </th><td>Presynaptic membrane, synaptic cleft</td></tr> |
| Molecular Weight | 200 kDa |
| GeneCards | NEUREXIN1 |
| Human Protein Atlas | NEUREXIN1 |
| Extracellular domain | Single LNS domain |
| Transmembrane region | Single-pass transmembrane helix |
| Cytoplasmic tail | Contains multiple PDZ-binding motifs for interaction with scaffolding proteins |
| Presynaptic differentiation | Induces formation of presynaptic specializations, including active zones and vesicle pools [@graf2004] |
| Synaptic specificity | Mediates recognition between pre- and postsynaptic partners |
| Active zone organization | Recruits scaffolding proteins and synaptic vesicles to presynaptic terminals |
| Synaptic maintenance | Sustains synaptic integrity throughout development and adulthood |
| Neurotransmitter release | Regulates vesicle docking, priming, and fusion |
| Receptor function | Modulates NMDA and AMPA receptor trafficking and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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