Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about bsn: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | BSN |
| Chromosome | 3p21.31 |
| Function | is a human gene that encodes one of the largest known synaptic proteins, with a molecular weight of approximately 420 kDa and about 3,948 amino acids[@gundelfinger2003]. |
| Molecular Weight | 420 kDa |
| Amino Acids | 948 aa |
| Exons | 63 |
| Ensembl ID | ENSG00000184961 |
| GeneCards | BSN |
| Human Protein Atlas | BSN |
| Hippocampus | Particularly high expression in CA3 pyramidal neurons and dentate gyrus granule cells, where Bassoon is enriched at mossy fiber synapses[@dieck1998] |
| Cerebral Cortex | Broad expression across all cortical layers, with particular enrichment in layer 2/3 pyramidal neurons |
| Cerebellum | Expression in Purkinje cells and granule cells |
| Retina | Very high expression in photoreceptor cells and bipolar cells, where Bassoon is a core component of synaptic ribbons |
| Substantia Nigra | Expression in dopaminergic neurons[@yoshida2012] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["BSN"]
N1["Aging"]
N0 -->|"expressed in"| N1
N2["Ms"]
N0 -->|"expressed in"| N2
N3["Depression"]
N0 -->|"expressed in"| N3
N4["GBA"]
N0 -->|"activates"| N4
N5["CELF4"]
N0 -->|"activates"| N5
N6["GUT-BRAIN AXIS"]
N6 -->|"regulates"| N0
N7["NRXN1"]
N7 -->|"activates"| N0
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:BSN | data_in | dataset_row | 0.00 |
| Ms | expressed_in | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Aging | expressed_in | disease | 0.65 |
| MAPT | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| PSP | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| GBA | activates | gene | 0.60 |
| CELF4 | activates | gene | 0.60 |
| CYLD | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:BSN | data_in | dataset_row | 0.00 |
| GUT-BRAIN AXIS | regulates | gene | 0.60 |
| ABCA7 | associated_with | gene | 0.60 |
| ATP13A2 | associated_with | gene | 0.60 |
| NRXN1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning bsn in their description or question text
No additional research found