| Gene Symbol | MUTYH |
| Aliases | MUTYHPROTEIN |
| Chromosome | 1p34.2 |
| Protein Type | Enzyme |
| Function | Without MUTYH, the mispaired adenine becomes fixed as a G:C to T:A mutation during replication. |
| Primary Expression | all tissues, with high expression in: - Brain: cerebral cortex, hippocampus, cerebellum - |
| Subcellular Localization | </strong> Nucleus (mitochondrial and nuclear)</div> |
| Molecular Weight | 52 kDa |
| Amino Acids | 479 aa |
| Exons | 16 |
| Pathways | DNA Repair |
| GeneCards | MUTYH |
| Human Protein Atlas | MUTYH |
| MUTYH Knockout Mice | Show increased mutation rates and cancer predisposition when challenged with oxidative stress. |
| MUTYH Transgenic Mice | Overexpression provides protection against oxidative stress-induced DNA damage and neurodegeneration in some models. |
| Associated Diseases | Als, cancer, neurodegeneration |
| Interactions | ATM, COMPLEMENT, CTC1, DNA, LMNA, MDM2 |
| KG Connections | 48 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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