pathway

LIPID METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPID METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2285Connections

6Hypotheses

0Analyses

50Outgoing

50Incoming

4Experiments

0Debates

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🔀 Pathway Info

Name	LIPID METABOLISM
Key Genes/Proteins	ABCA7, ACSL4, AKT, AMPK, AMYLOID
Related Diseases	aging, ALS, ALZHEIMER, Alzheimer Disease, Alzheimer'S Disease
Related Pathways	AMPK PATHWAY

Pathway Diagram

graph TD
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"associated"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"contributes to"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"contributes to"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"contributes to"| SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    style SYNAPTIC_PLASTICITY fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"associated"| KIDNEY_FIBROSIS["KIDNEY FIBROSIS"]
    style KIDNEY_FIBROSIS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"expressed in"| TNF["TNF"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CLOCK["CLOCK"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style CLOCK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style BMAL1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PLIN2["PLIN2"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style PLIN2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    RUBCN["RUBCN"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style RUBCN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PER["PER"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style PER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style LIPID_METABOLISM fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (346)

Target	Relation	Type	Str
Glioblastoma	promotes	disease	0.95
Phospholipid Peroxidation	regulates	mechanism	0.95
Ferroptosis	modulates	process	0.95
neurons	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
Sebaceous Glands	expressed_in	cell_type	0.90
Flavivirus Replication	involved_in	process	0.90
oligodendrocytes	active_in	cell_type	0.90
unfolded protein response	crosstalk_with	pathway	0.90
microglia	active_in	cell_type	0.90
Glioblastoma	contributes_to	disease	0.90
ALZHEIMER'S DISEASE	associated_with	entity	0.90
Ferroptosis Sensitivity	modulates	phenotype	0.90
PARKINSON'S DISEASE	associated_with	entity	0.90
astrocytes	active_in	cell_type	0.90
Glioblastoma Progression	associated_with	process	0.85
Alzheimer'S Disease	involved_in	disease	0.85
Flavivirus Infection	associated_with	disease	0.85
Myelin Stability	regulates	phenotype	0.85
Myelin Composition	regulates	phenotype	0.85
Tau pathology	modulates	process	0.85
Cognitive Resilience	contributes_to	phenotype	0.85
Preimplantation Development	associated_with	process	0.85
Amyloid-beta pathology	modulates	process	0.85
OXIDATIVE STRESS	associated_with	entity	0.85
NEUROINFLAMMATION	associated_with	entity	0.85
Amyloidogenesis	interacts_with	mechanism	0.85
Neuroinflammation	modulates	process	0.80
RUBCN	regulates	gene	0.80
macrophages	active_in	cell_type	0.80
Kidney Fibrosis	contributes_to	disease	0.80
cognitive resilience	protects_against	phenotype	0.80
Oxidative Stress	modulates	process	0.80
SYNAPTIC PLASTICITY	contributes_to	entity	0.80
KIDNEY FIBROSIS	associated_with	entity	0.80
Tau-Mediated Degeneration	contributes_to	process	0.80
metabolic syndrome	involved_in	disease	0.80
Bioenergetic Deficit	interacts_with	mechanism	0.75
Myelin Degeneration	associated_with	process	0.75
ferroptosis	regulates	process	0.70
neurodegenerative diseases	associated_with	disease	0.70
sphingolipid signaling	crosstalk_with	pathway	0.70
blood-brain barrier	active_in	brain_region	0.70
INSULIN RESISTANCE	treats	phenotype	0.70
cortex	active_in	brain_region	0.70
neuroinflammation	regulates	process	0.70
oxidative stress	regulates	process	0.70
amyloidogenesis	interacts_with	process	0.70
OXIDATIVE STRESS	causes	phenotype	0.65
PODOCYTES	activates	cell_type	0.65

Incoming (1939)

Source	Relation	Type	Str
FERROPTOSIS	regulates	gene	1.00
Diabetes	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
APOPTOSIS	activates	gene	1.00
ALZHEIMER	regulates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
CANCER	inhibits	gene	1.00
Als	associated_with	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
INFLAMMATION	associated_with	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
Obesity	activates	disease	1.00
Aging	activates	disease	1.00
Inflammation	activates	disease	1.00
Cancer	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
Inflammation	associated_with	disease	1.00
CANCER	regulates	gene	1.00
Als	inhibits	disease	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
AUTOPHAGY	activates	gene	1.00
AMPK	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
SIRT1	activates	gene	1.00
CYTOKINES	activates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
ALZHEIMER	associated_with	gene	1.00
INFLAMMATION	regulates	gene	1.00
AKT	regulates	gene	1.00
PI3K	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
Tumor	regulates	disease	1.00
IL-6	activates	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
APOE	associated_with	gene	1.00
Alzheimer	regulates	disease	1.00
OXIDATIVE STRESS	regulates	gene	1.00
Fibrosis	activates	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
APOPTOSIS	regulates	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
Als	activates	disease	1.00
Diabetes	regulates	disease	1.00
Obesity	regulates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	regulates	gene	1.00

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 Deficiency Drives Microglial Senescence via Lipid Meta	0.800	neurodegeneration	What molecular mechanisms drive microgli
Regional TREM2-Dependent Lipid Metabolism Determines Cortica	0.710	neuroinflammation	How do regional, age, and sex-dependent
Sphingolipid Metabolism Reprogramming	0.663	neurodegeneration	4R-tau strain-specific spreading pattern
Astrocyte APOE4-Specific Lipid Metabolism Correction	0.651	neurodegeneration	Cell type vulnerability in Alzheimers Di
APOE4-Lipid Metabolism Correction	0.610	neurodegeneration	Neuroinflammation and microglial priming

TREM2 Epigenetic Window for Microglial Lipid Metabolism	0.525	neurodegeneration	What is the optimal therapeutic window d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CERS2 genetic deletion rescues IL-10 deficiency inflammation	validation	inflammatory bowel disease	0.850	0.00	IL-10/CERS2 double knockout mi	proposed	N/A
Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Validation: Membrane-Nucleation in iPSC Neurons	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism [PMID:40624017]	Li L, Lei Y, Li Y, Xie Y, Hui P, Zang X,	Nat Commun	2025	1
IL-10 constrains sphingolipid metabolism to limit inflammation. [PMID:38383790]	York AG, Skadow MH, Oh J, Qu R, Zhou QD,	Nature	2024	1
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ce [PMID:38961186]	Zhu Q, Chen S, Funcke JB, Straub LG, Lin	Nat Metab	2024	1
Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271]	Mushtaq T, Hameed H, Khan MA, Tariq U, H	Molecular neurobiology	2026	0
Resibufogenin protects against atherosclerosis in ApoE(-/-) mice through blockin [PMID:40258472]	Xiaoyang C, Yijun C, Chenguang Z, Wanyin	J Adv Res	2026	0
High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402]	Du Y, Borné Y, Samuelsson J, Glans I, Hu	Neurology	2026	0
Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Fo [PMID:41410044]	Zhang J, Yu L, Yang W, Cao L, Wang X et	Circulation	2026	0
The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736]	Abedin MJ, Kastanenka KV	J Alzheimers Dis	2026	0
Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808]	Acharya A, Ambikan AT, Neogi U, Lamberty	Res Sq	2026	0
Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475]	Dang TN, Ghosh B, Panta PR, Taylor JM, K	J Lipid Res	2026	0
Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246]	Strickland MR, Wang Z, Golden LR, Wang H	J Lipid Res	2026	0
Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier f [PMID:41856194]	Ma X, Liu Q, Mai K, Zhang Y	Int J Biol Macromol	2026	0
HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381]	Hjæresen S, Gramkow ET, Zhang M, Svennin	Prog Neurobiol	2026	0
Alzheimer's disease basics: we all should know. [PMID:40639927]	Das S	Neurological research	2026	0
Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzhe [PMID:41890452]	Arriaga P, Vianna K, Montez C, Panariell	Cureus	2026	0
Genetic modifiers of APOE-ε4-associated cognitive decline. [PMID:41720779]	Contreras AG, Walters S, Eissman JM, Arc	Nature communications	2026	0
Protective ApoE variants support neuronal function by effluxing oxidized phospho [PMID:41338186]	Ralhan I, Do AD, Bae JY, Feringa FM, Cai	Neuron	2026	0
Metabolic abnormalities and reprogramming in cats with naturally occurring hyper [PMID:39499136]	["Li Q", "Homilius M", "Achilles E", "Ma	ESC heart failure	2025	0
Reduced circulating sphingolipids and CERS2 activity are linked to T2D risk and [PMID:39792658]	Khan SR, Ye WW, Van JAD, Singh I, Rabiee	Science advances	2025	0
Very long-chain fatty acids drive 1-deoxySphingolipid toxicity. [PMID:41298489]	["Majcher A", "Karsai G", "Yusifov E", "	Nature communications	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIPID METABOLISM in their description or question text

TREM2 Epigenetic Window for Microglial Lipid Metabolism

Score: 0.525 · neurodegeneration · 2026-04-21

## Mechanistic Overview TREM2 Epigenetic Window for Microglial Lipid Metabolism starts from the claim that modulating TR