Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about XPC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
XPC encodes a key DNA damage recognition protein in global genome nucleotide excision repair (GG-NER), essential for DNA repair and genome integrity
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| Gene Symbol | XPC |
| Full Name | Xeroderma Pigmentosum Complementation Group C |
| Aliases | GG-NER |
| Chromosome | 3p25.1 |
| Function | encodes a protein critical for DNA nucleotide excision repair (NER). |
| Pathways | Apoptosis |
| UniProt ID | [Q01831](https://www.uniprot.org/uniprot/Q01831) |
| Ensembl ID | ENSG00000154767 |
| GeneCards | XPC |
| Human Protein Atlas | XPC |
| XPC | The DNA damage recognition subunit |
| RAD23B | Stabilizes XPC and links to the proteasome |
| CETN2 | Calcium-binding protein that aids in damage verification |
| DNA damage recognition domain | Binds to helix-distorting lesions |
| RAD23B-binding domain | Mediates complex formation |
| Associated Diseases | ALS, Cancer |
| Interactions | AKT, APOPTOSIS, DNA, LATS1, SIRT1, UVRAG |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
XPC["XPC"]
Cancer{"Cancer"}
XPC -->|"associated with"| Cancer
Tumor{"Tumor"}
XPC -->|"inhibits"| Tumor
XPC -->|"regulates"| Tumor
CANCER["CANCER"]
XPC -->|"associated with"| CANCER
APOPTOSIS["APOPTOSIS"]
XPC -->|"activates"| APOPTOSIS
AUTOPHAGY["AUTOPHAGY"]
XPC -->|"associated with"| AUTOPHAGY
Apoptosis(["Apoptosis"])
XPC -->|"activates"| Apoptosis
Autophagy(["Autophagy"])
XPC -->|"associated with"| Autophagy
TFR1["TFR1"]
XPC -->|"regulates"| TFR1
neurodegeneration["neurodegeneration"]
XPC -->|"implicated in"| neurodegeneration
UVRAG["UVRAG"]
UVRAG -->|"activates"| XPC
PIK3C3["PIK3C3"]
PIK3C3 -->|"therapeutic target"| XPC
LATS1["LATS1"]
LATS1 -->|"activates"| XPC
P53["P53"]
P53 -->|"regulates"| XPC
style XPC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | regulates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| APOPTOSIS | activates | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| TFR1 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-SYK Signaling Axis Couples OxPC Recognition to Phagocy | 0.453 | neuroinflammation | What molecular mechanisms enable microgl |
| Complement Cascade Activation Bridges Microglial OxPC Sensin | 0.419 | neuroinflammation | What molecular mechanisms enable microgl |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning XPC in their description or question text
No additional research found