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gene 1,563 words KG: HDAC9
Contents

HDAC9 Gene

🧬 Gene Info
Gene SymbolHDAC9
Full NameHistone Deacetylase 9
Chromosome7p21.1
Functionencodes a class IIa histone deacetylase that plays crucial roles in epigenetic regulation, transcriptional control, and cellular signaling in the brain.
Primary ExpressionBrain, heart, skeletal muscle
Molecular Weight110 kDa
UniProt IDQ9UKV0
NCBI Gene ID9734
Ensembl IDENSG00000048828
OMIM606365
GeneCardsHDAC9
Human Protein AtlasHDAC9
Associated DiseasesAls, Coronary Artery Disease, Inflammation, Stroke
InteractionsHDAC, HDAC5, INFLAMMATION, KDR, METTL3, NANOG
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (16)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73CYP46A1 Overexpression Gene Therapy
Score: 0.95Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Circadian Clock-Autophagy Synchronization
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Circadian-Synchronized Proteostasis Enhancement
Score: 0.74APOE Isoform Expression Across Glial Subtypes
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Ocular Immune Privilege Extension
Score: 0.69Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_inGenes
index · KG edge: associated_withALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: associated_withATM Gene
gene · KG edge: associated_withMEF2D — Myocyte Enhancer Factor 2D
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MEF2D associated_with HDAC9
MMP12 associated_with HDAC9
HDAC9 associated_with ALDH2
HDAC9 associated_with APOE
ATM associated_with HDAC9
HDAC5 co_expressed_with HDAC9
HDAC9 co_expressed_with NRF2
HDAC5 associated_with HDAC9
HDAC5 inhibits HDAC9
HDAC5 activates HDAC9

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