| Gene Symbol | TCF3 |
| Full Name | Transcription Factor 3 |
| Chromosome | 19p13.3 |
| Protein Type | Transcription Factor |
| Function | is a basic helix-loop-helix (bHLH) transcription factor that plays critical roles in lymphocyte development, myogenesis, and neurogenesis [@e2a_bhlh_2011]. |
| Primary Expression | the ventricular zone (VZ) and subventricular zone (SVZ), where neural stem cells reside |
| Pathways | Notch, Wnt, Notch signaling |
| UniProt ID | P15923 |
| NCBI Gene ID | 6929 |
| Ensembl ID | ENSG00000171539 |
| GeneCards | TCF3 |
| Human Protein Atlas | TCF3 |
| Basic region | DNA-binding domain that contacts E-box consensus sequences (CANNTG) |
| Helix-loop-helix domain | Mediates protein-protein dimerization with other bHLH factors |
| Activation domains | Two transcriptional activation domains (AD1 and AD2) at the N-terminus |
| Associated Diseases | Leukemia, Cognitive Impairment, Neurodevelopmental Disorders |
| Interactions | AND, CANCER, CTNNB1, EP300, FGFR3, GENE MUTATIONS |
| KG Connections | 64 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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