gene 1,287 words KG: TRAF3
Contents

TRAF3

🧬 Gene Info
Gene SymbolTRAF3
Full NameTNF Receptor-Associated Factor 3
Chromosome4p12
Protein TypeReceptor
Functionis a crucial signaling adapter protein that regulates multiple innate immune signaling pathways, including NF-κB, MAPK, and type I interferon responses.
Gene TypeProtein Coding
PathwaysNF-κB, nfkb, MAPK, NF-κB Signaling
UniProt IDQ9Y4K0
NCBI Gene ID7188
Ensembl IDENSG00000126777
GeneCardsTRAF3
Human Protein AtlasTRAF3
Associated DiseasesAls, Tumor
InteractionsCAT, CBL, IFN, INFLAMMATION, ISG15, LC3
KG Connections58 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (3)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (15)

blarcamesine-axon
clinical_trial · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
TNF (Redirect)
redirect · KG edge: activates
ASC (PYCARD)
gene · KG edge: regulates
CACNA1E Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

TNF activates TRAF3
MYD88 associated_with TRAF3
TRAF3 inhibits TLR4
TRAF3 inhibits CAT
TRAF3 inhibits UBIQUITIN
TRAF3 regulates TRAF6
TRAF3 regulates NDP52
TRAF3 inhibits LC3
CBL activates TRAF3
NLRP3 regulates TRAF3

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