| Gene Symbol | PRPF3 |
| Full Name | Pre-mRNA Processing Factor 3 |
| Aliases | PRPF3PROTEIN |
| Chromosome | 1q21.1 |
| Function | is a critical step in eukaryotic gene expression that removes non-coding introns and joins coding exons to produce mature messenger RNA. |
| Subcellular Localization | </th><td>Nucleus (spliceosome)</td></tr> |
| Molecular Weight | 75 kDa |
| Amino Acids | 683 aa |
| Exons | 16 |
| UniProt ID | [O43371](https://www.uniprot.org/uniprot/O43371) |
| Ensembl ID | ENSG00000148408 |
| GeneCards | PRPF3 |
| Human Protein Atlas | PRPF3 |
| Middle region | Forms the core interaction surface with other tri-snRNP components, including direct contacts with PRPF31 and PRPF4. This region (residues 300-500) serves as the central hub for complex assembly. |
| C-terminal domain | Participates in spliceosome activation and catalytic steps. The C-terminal region (residues 500-683) contains additional regulatory elements and post-translational modification sites. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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