Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about R-LOOP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | R-LOOP |
graph TD
R_LOOP[R-LOOP]
R_LOOP -->|mediates| Rna_Dna_Hybrid[Rna-Dna Hybrid]
R_LOOP -->|activates| Immune_Response[Immune Response]
R_LOOP -->|causes| Dna_Damage[Dna Damage]
R_LOOP -->|causes| Genome_Instability[Genome Instability]
R_LOOP -->|promotes| Human_Papillomavirus_Infection[Human Papillomavirus Infection]
SETX[SETX] -->|regulates| R_LOOP
Sirna_Treatment[Sirna Treatment] -->|upregulates| R_LOOP
SETX_mutation__c_1166T_C_[SETX mutation (c.1166T>C)] -->|downregulates| R_LOOP
m6A_modification[m6A modification] -->|suppresses| R_LOOP
siRNA_targeting_SETX[siRNA targeting SETX] -->|upregulates| R_LOOP| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Response | activates | process | 0.95 |
| Rna-Dna Hybrid | mediates | compound | 0.95 |
| Amyotrophic Lateral Sclerosis Type 4 | associated_with | disease | 0.92 |
| Dna Damage | causes | phenotype | 0.90 |
| Genome Instability | causes | phenotype | 0.90 |
| Human Papillomavirus Infection | promotes | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SETX | regulates | protein | 0.95 |
| Sirna Treatment | upregulates | drug | 0.92 |
| SETX | interacts_with | protein | 0.90 |
| SETX | involved_in | protein | 0.90 |
| SETX mutation (c.1166T>C) | downregulates | compound | 0.90 |
| m6A modification | suppresses | process | 0.88 |
| SETX | biomarker_for | protein | 0.85 |
| siRNA targeting SETX | upregulates | drug | 0.80 |
| SETX | regulates | gene | 0.80 |
| SETX | binds | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| R-Loop Resolution Enhancement Therapy | 0.680 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allele-specific silencing of a dominant SETX mutation in familial amyotrophic la [PMID:40200577] | Winkelsas A, Apfel A, Johnson B, Harmiso | HGG Adv | 2025 | 1 |
| SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy [PMID:32686621] | Richard P, Feng S, Tsai YL, Li W, Rinche | Autophagy | 2021 | 1 |
| Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent D [PMID:31533039] | Cristini A, Ricci G, Britton S, Salimben | Cell Rep | 2019 | 1 |
| Molecular characterization of recessively inherited ataxic and neuropathic disor [PMID:41606223] | ["Aslam F", "Wajid M", "Butt A", "Wohler | Scientific reports | 2026 | 0 |
| Deciphering ALS-linked genetic variants in indian patients using targeted and ex [PMID:41137727] | ["Reza S", "Handique J", "Sharma P", "Ma | Amyotrophic lateral sclerosis | 2026 | 0 |
| Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017] | Aynaashe A, Kursula P | Amino Acids | 2026 | 0 |
| Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017] | Aynaashe A, Kursula P | Amino acids | 2026 | 0 |
| N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to con [PMID:41518615] | ["Templeton C", "Laimins L"] | Cell reports | 2026 | 0 |
| The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-rep [PMID:41533569] | Wu T, Li Y, Zhao Y, Bournique E, Ortega | Nucleic acids research | 2026 | 0 |
| Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD [PMID:41917467] | Dutta A, Ji JH, Syed S, Fang Q, Mukhopad | Nature structural & molecular | 2026 | 0 |
| Ataxia and oculomotor apraxia caused by a large-scale deletion in the senataxin [PMID:40830689] | ["Rusecka J", "Kierdaszuk B", "St\u0119p | Journal of applied genetics | 2025 | 0 |
| Unraveling the genetic landscape of ALS in Greece: identification of known and n [PMID:41196070] | ["Kartanou C", "Kontogeorgiou Z", "Loupi | Amyotrophic lateral sclerosis | 2025 | 0 |
| Break-induced replication is activated to repair R-loop-associated double-strand [PMID:40475435] | ["Wu T", "Li Y", "Shi L", "Wu X"] | bioRxiv : the preprint server | 2025 | 0 |
| A role for human senataxin in contending with pausing and backtracking during tr [PMID:41232527] | Han Z, Fu S, Johansen JV, Lopez Martinez | Molecular cell | 2025 | 0 |
| Break-induced replication is activated to repair R-loop-associated double-strand [PMID:41037402] | Wu T, Li Y, Zhao Y, Shah SB, Shi LZ, Wu | Cell reports | 2025 | 0 |
| Unveiling ten novel SETX mutations: implications for ALS pathogenesis and clinic [PMID:40338003] | ["Chen X", "Chen X", "Lin X", "Zhou W", | Somatosensory & motor research | 2025 | 0 |
| ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics [PMID:41305523] | Moffitt R, Brooks S, Androphy EJ, DeSmet | Viruses | 2025 | 0 |
| Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration [PMID:37558082] | ["Giannini M", "Porrua O"] | Biochimie | 2024 | 0 |
| Role of senataxin in R-loop-mediated neurodegeneration. [PMID:39070547] | Kannan A, Gangadharan Leela S, Branzei D | Brain communications | 2024 | 0 |
| Helicases in R-loop Formation and Resolution. [PMID:37778731] | Yang S, Winstone L, Mondal S, Wu Y | The Journal of biological chem | 2023 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning R-LOOP in their description or question text
No additional research found