concept

SIRTUINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRTUINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

15Outgoing

1Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SIRTUINS
Key Genes/Proteins	HISTONE_DEACETYLASE
Related Diseases	APOPTOSIS, Cardiovascular Disease, CARDIOVASCULAR_DISEASE, CELLULAR_SENESCENCE, DISEASE
Related Pathways	CELLULAR_METABOLISM

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sirtuins in Neurodegeneration

mechanism · 1084 words

→

Pathway Diagram

graph TD
    SIRTUINS["SIRTUINS"]
    SIRTUINS -->|"catalyzes"| Histone_Deacetylation["Histone Deacetylation"]
    SIRTUINS -->|"modulates"| Ageing["Ageing"]
    SIRTUINS -->|"involved_in"| Cardiovascular_Disease["Cardiovascular Disease"]
    SIRTUINS -->|"regulates"| Cellular_Metabolism["Cellular Metabolism"]
    SIRTUINS -->|"modulates"| DNA_Damage["DNA Damage"]
    SIRTUINS -->|"encodes"| HISTONE_DEACETYLASE["HISTONE_DEACETYLASE"]
    Nad_["Nad+"] -->|"regulates"| SIRTUINS
    TULP3["TULP3"] -->|"activates"| SIRTUINS
    NAD["NAD"] -->|"interacts"| SIRTUINS

Outgoing (15)

Target	Relation	Type	Str
Ageing	modulates	process	0.90
Ageing	suppresses	process	0.90
Cardiovascular Disease	involved_in	disease	0.90
Cellular Metabolism	regulates	process	0.85
DNA Damage	modulates	process	0.80
AGING	regulates	process	0.80
DISEASE	implicated_in	disease	0.80
HISTONE_DEACETYLASE	encodes	protein	0.72
APOPTOSIS	regulates	phenotype	0.72
DNA_DAMAGE	regulates	phenotype	0.64
CELLULAR_METABOLISM	regulates	pathway	0.64
CARDIOVASCULAR_DISEASE	associated_with	disease	0.64
CARDIOVASCULAR_SYSTEM	expressed_in	cell_type	0.64
OXIDATIVE_STRESS	regulates	phenotype	0.64
CELLULAR_SENESCENCE	regulates	phenotype	0.64

Incoming (1)

Source	Relation	Type	Str
TULP3	activates	protein	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIRTUINS in their description or question text

No additional research found