mechanism 1,225 words KG: ent-gene-62420ab9
Contents

DCTN1 Dynactin Perry Syndrome Causal Chain

🔬 Protein Info
Gene Symbolent-gene-62420ab9
Causality strengthStrong - DCTN1 mutations cause Perry syndrome with high penetrance
Population frequencyVery rare (<0.0001% of population)
Age of onsetTypically 45-65 years
SegregationAutosomal dominant inheritance demonstrated in multiple families
Unique featureDCTN1 mutations cause both atypical parkinsonism (Perry) and ALS phenotypes
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Vocal Cord Neuroplasticity Stimulation
Score: 0.52

Related Analyses (27)

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Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-62420ab9 data_in benchmark_ot_ad_answer_key:DCTN1
benchmark_ot_ad_answer_key:DCTN1 data_in ent-gene-62420ab9

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