gene

PLK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

40Outgoing

17Incoming

0Experiments

0Debates

Summary

PLK2 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates, phosphorylates. Associated with Als, Ischemia, Ms. Connected to 28 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLK2
Full Name	Polo-Like Kinase 2
Chromosome	5q12.1
Protein Family	Polo-like kinase (PLK) family
Protein Type	Kinase
Function	is a serine/threonine protein kinase that plays critical roles in cellular homeostasis, synaptic function, and stress responses.
Primary Expression	neuronal tissue and playing essential roles in brain function [@wong2008]
Molecular Weight	71 kDa
Amino Acids	657 aa
UniProt ID	Q9NYY3
NCBI Gene ID	10769
Ensembl ID	ENSG00000145631
GeneCards	PLK2
Human Protein Atlas	PLK2
Autophosphorylation	PLK2 can autophosphorylate itself, which may regulate its activity and stability
Associated Diseases	Als, Ischemia, neurodegeneration, Parkinson, Stroke
Known Drugs/Compounds	levodopa
Interactions	AND, ERK2, NEURODEGENERATION, PARKINSON, SNCA, Α-Synuclein
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLK2 — AlphaFold Q9NYY3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PLK2 Gene

gene · 2200 words

→

PLK2 Protein

protein · 1074 words

→

Pathway Diagram

graph TD
    PLK2["PLK2"]
    PLK2_PROTEIN["PLK2_PROTEIN"]
    PLK2 -->|"encodes"| PLK2_PROTEIN
    Neurodegeneration{"Neurodegeneration"}
    PLK2 -->|"contributes to"| Neurodegeneration
    Ms{"Ms"}
    PLK2 -->|"contributes to"| Ms
    Parkinson{"Parkinson"}
    PLK2 -->|"activates"| Parkinson
    PLK2 -->|"phosphorylates"| Neurodegeneration
    SNCA["SNCA"]
    PLK2 -->|"activates"| SNCA
    neurodegeneration["neurodegeneration"]
    PLK2 -->|"implicated in"| neurodegeneration
    SNCA -->|"activates"| PLK2
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| PLK2
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"phosphorylates"| PLK2
    AND["AND"]
    AND -->|"activates"| PLK2
    style PLK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
SNCA aggregation	enhances	pathway	0.90
SNCA Aggregation	associated_with	process	0.90
Autophagy	inhibits	process	0.88
Parkinson's Disease	risk_factor_for	disease	0.85
SNCA	phosphorylates	entity	0.85
PLK2_PROTEIN	encodes	protein	0.80
SNCA clearance	inhibits	pathway	0.80
macroautophagic flux	inhibits	pathway	0.80
autophagy	inhibits	pathway	0.80
α-synuclein	regulates	protein	0.80
neurotoxicity	enhances	pathway	0.80
LC3	regulates	entity	0.75
Neurodegeneration	implicated_in	disease	0.75
DCTN1	associated_with	protein	0.70
Neurodegeneration	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	phosphorylates	disease	0.65
Parkinson	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Ischemia	implicated_in	disease	0.65
Stroke	implicated_in	disease	0.65
NEURODEGENERATION	implicated_in	gene	0.60
NEURODEGENERATION	phosphorylates	gene	0.60
AND	activates	gene	0.60
neurodegeneration	causes	disease	0.60
Α-Synuclein	activates	protein	0.60
NEURODEGENERATION	contributes_to	gene	0.60
Apoptosis	implicated_in	pathway	0.60
Autophagy	implicated_in	pathway	0.60
SNCA	activates	gene	0.60
DRP1	implicated_in	gene	0.60
Oxidative Stress	implicated_in	pathway	0.60
AUTOPHAGY	implicated_in	gene	0.60
SNCA	expressed_in	entity	0.60
SNCA	regulates	entity	0.60
PARKINSON	activates	gene	0.60
SNCA	causes	gene	0.60
α-SYNUCLEIN	activates	concept	0.50
SYNUCLEIN	activates	concept	0.50

Incoming (17)

Source	Relation	Type	Str
levodopa	targets	drug	0.60
NEURODEGENERATION	phosphorylates	gene	0.60
STROKE	implicated_in	gene	0.60
APOPTOSIS	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
PARKINSON'S DISEASE	implicated_in	gene	0.60
OXIDATIVE STRESS	implicated_in	gene	0.60
PARKINSON	implicated_in	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
SNCA	activates	gene	0.60
ERK2	inhibits	gene	0.60
PARKINSON	activates	gene	0.60
SNCA	associated_with	gene	0.50
Neurodegeneration	associated_with	disease	0.50
SNCA	regulates	gene	0.50
SNCA	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLK2 in their description or question text

No additional research found