| Gene Symbol | DCTN1 |
| Full Name | Dynactin Subunit 1 (p150^Glued) |
| Aliases | Dynactin subunit p150^Glued |
| Protein Family | Dynactin complex |
| Function | DCTN1 plays critical roles in neuronal function |
| Subcellular Localization | Cytoplasm, neuronal axons, growth cones |
| Molecular Weight | 150 kDa |
| Amino Acids | 238 aa |
| UniProt ID | Q14203 |
| GeneCards | DCTN1 |
| Human Protein Atlas | DCTN1 |
| Microtubule plus-ends | Direct interaction with the extreme plus-end of microtubules facilitates transport initiation[@lazarus2013] |
| EB proteins | EBs (EB1, EB3) at microtubule tips serve as DCTN1 landing pads[@goodman2017] |
| CLIP-170 family proteins | Additional plus-end tracking proteins that can recruit DCTN1[@lansbery2002] |
| Tubulin dimers | Direct interaction with polymerized tubulin[@lazarus2013] |
| Associated Diseases | ALS, frontotemporal dementia |
| Interactions | Actin, ARF6, ATG, DYNACTIN, Dynein, DYNEIN |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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