gene 1,361 words KG: CHIT1
Contents

CHIT1 Gene (Chitinase 1)

🧬 Gene Info
Gene SymbolCHIT1
Full NameChitinase 1
Chromosome1q32.1
Protein TypeEnzyme
Functionencodes a hydrolytic enzyme that degrades chitin, a polymer of N-acetylglucosamine found in fungal cell walls, insect exoskeletons, and some parasites.
Molecular Weight50 kDa
Amino Acids466 aa
Exons12
Pathwaysoxidative stress response
UniProt IDQ01228
NCBI Gene ID1118
Ensembl IDENSG00000133093
OMIM607203
GeneCardsCHIT1
Human Protein AtlasCHIT1
Associated DiseasesInflammation, Neuroinflammation
InteractionsAND, AXL, CHI3L1, CXCL1, CXCL10, CXCL9
KG Connections126 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
AXL - AXL Receptor Tyrosine Kinase
gene · KG edge: inhibits
BDNF Gene
gene · KG edge: biomarker_for
CHI3L1 Gene
gene · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: biomarker_for

Knowledge Graph (12 edges)

CXCL1 therapeutic_target CHIT1
CXCL10 therapeutic_target CHIT1
CHIT1 inhibits AXL
CHIT1 therapeutic_target MMP12
IL9 biomarker_for CHIT1
VEGFA associated_with CHIT1
IL4 biomarker_for CHIT1
FGF2 biomarker_for CHIT1
GFAP biomarker_for CHIT1
NPTX1 associated_with CHIT1

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