gene

AQUAPORIN-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AQUAPORIN-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

453Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

14Experiments

0Debates

Summary

AQUAPORIN-4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, causes. Associated with ALS, Aging, Als. Connected to 84 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AQUAPORIN
Full Name	Aquaporin 4
Aliases	AQP4, MIWC, WCH4
Chromosome	18q11.2
Protein Family	Aquaporin (AQP) family
Function	Water channel protein; forms orthogonal arrays in astrocyte endfeet. Critical for brain water homeostasis and glymphatic clearance.
Primary Expression	Astrocyte endfeet, kidney collecting duct, ependymal cells
Subcellular Localization	Astrocyte end-feet, perivascular, ependymal
Molecular Weight	34.8 kDa
Gene Type	Protein-coding
Pathways	Vasopressin-regulated water reabsorption, Glymphatic clearance
UniProt ID	P55064
GeneCards	AQUAPORIN
Human Protein Atlas	AQUAPORIN
Associated Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Autoimmune
Interactions	ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, AND
KG Connections	448 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: AQUAPORIN-4 — AlphaFold P55064 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AQP4 Protein — Aquaporin 4

protein · 766 words

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Pathway Diagram

graph TD
    AQUAPORIN_4["AQUAPORIN-4"] -->|"regulates"| Aging["Aging"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| Autoimmune["Autoimmune"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| ALS["ALS"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| Cancer["Cancer"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"associated"| Multiple_Sclerosis_1["Multiple Sclerosis"]
    AMYLOID["AMYLOID"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    JUN["JUN"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    AQP4["AQP4"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    style AQUAPORIN_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (330)

Target	Relation	Type	Str
Glymphatic System	participates_in	biological_process	0.90
Glymphatic System	associated_with	pathway	0.90
Neurological Impairment	regulates	disease	0.80
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.80
Central Nervous System Disorders	associated_with	disease	0.80
Clearance Function	regulates	process	0.80
Diabetes	regulates	disease	0.65
Alzheimer	causes	disease	0.65
Heart Failure	regulates	disease	0.65
Als	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Alzheimer	transports	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Retinopathy	transports	disease	0.65
Retinal Degeneration	transports	disease	0.65
Lymphoma	activates	disease	0.65
Sepsis	associated_with	disease	0.65
Aging	activates	disease	0.65
Aging	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Ischemia	activates	disease	0.65
Ms	causes	disease	0.65
Dementia	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Als	causes	disease	0.65
ALS	expressed_in	disease	0.65
Als	regulates	disease	0.65
Stroke	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Prion	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Epilepsy	activates	disease	0.65
Tumor	activates	disease	0.65
Encephalitis	activates	disease	0.65
Ms	regulates	disease	0.65
Diabetes	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65

Incoming (123)

Source	Relation	Type	Str
AMYLOID	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
JUN	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
COMPLEMENT	causes	gene	0.60
AQP4	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
AQP4	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
OLIGODENDROCYTE	biomarker_for	gene	0.60
MOG	biomarker_for	gene	0.60
EMD	activates	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ASTROCYTES	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PROINFLAMMATORY CYTOKINES	associated_with	gene	0.60
OLIGODENDROCYTE	causes	gene	0.60
PARKINSON	inhibits	gene	0.60
ATP	regulates	gene	0.60
MMP9	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
ABCB1	regulates	gene	0.60
TAU	causes	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
ANG	expressed_in	gene	0.60
TAU	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
STROKE	activates	gene	0.60
EPILEPSY	activates	gene	0.60
AMYLOID	activates	gene	0.60
NEPRILYSIN	regulates	gene	0.60
GRIN2A	activates	gene	0.60
MYELIN	therapeutic_target	gene	0.60
CR2	inhibits	gene	0.60
ALZHEIMER	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
AXON	transports	gene	0.60
DEMENTIA	associated_with	gene	0.60
AQP4	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ATM	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Driven Aquaporin-4 Dysregulation	0.782	neurodegeneration	Senolytic therapy for age-related neurod
Aquaporin-4 Polarization Rescue	0.732	neurodegeneration	4R-tau strain-specific spreading pattern
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu	0.668	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (14)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
TREK-1 regulation of conventional outflow facility in mouse eyes	validation	ocular hypertension	0.900	0.00	mouse eyes	proposed	N/A
DEX effects on TREK-1 currents in human primary TM cells	exploratory	corticosteroid-induced ocular	0.900	0.00	primary human trabecular meshw	proposed	N/A
TREK-1 effects on IOP in DEX-induced mouse OHT model	validation	dexamethasone-induced ocular h	0.900	0.00	mouse eyes	proposed	N/A
DEX effects on K2P channel transcriptome in mouse TM cells	exploratory	corticosteroid-induced ocular	0.900	0.00	mouse trabecular meshwork cell	proposed	N/A
TREK-1 effects on spontaneous OHT in rats using telemetry	validation	spontaneous ocular hypertensio	0.800	0.00	rat eyes	proposed	N/A
TREK-1 localization in trabecular meshwork by immunohistochemistry	exploratory	ocular hypertension	0.800	0.00	trabecular meshwork tissue	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$240,000
s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$260,000
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
NPH Glymphatic System Interaction Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Aquaporin-4 in glymphatic system, and its implication for central nervous system [PMID:36796590]	Peng S, Liu J, Liang C, Yang L, Wang G	Neurobiol Dis	2023	2
Uncommon inflammatory/immune-related myelopathies. [PMID:34715593]	Valencia-Sanchez C, Flanagan EP	J Neuroimmunol	2021	2
Novel function of TREK-1 in regulating adipocyte differentiation and lipid accum [PMID:40057491]	Kim A, Jung S, Kim Y, Jung J, Lee S, Lee	Cell Death Dis	2025	1
Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978]	Redmon SN, Yarishkin O, Rudzitis CN, Lak	Invest Ophthalmol Vis Sci	2025	1
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. [PMID:38383779]	Afzali AM, Nirschl L, Sie C, Pfaller M,	Nature	2024	1
Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A- [PMID:36410022]	Zyrianova T, Lopez B, Zou K, Gu C, Pham	Am J Physiol Lung Cell Mol Phy	2023	1
Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressu [PMID:31959516]	Reeves BC, Karimy JK, Kundishora AJ, Mes	Trends Mol Med	2020	1
Inebilizumab-cdon. [PMID:32936251]	Unknown	American journal of health-sys	2020	1
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci f [PMID:30061609]	Wyss AB, Sofer T, Lee MK, Terzikhan N, N	Nat Commun	2018	1
The glymphatic pathway in neurological disorders. [PMID:30353860]	Rasmussen MK, Mestre H, Nedergaard M	Lancet Neurol	2018	1
Temperature sensitivity of two-pore (K2P) potassium channels. [PMID:25366235]	Schneider ER, Anderson EO, Gracheva EO,	Curr Top Membr	2014	1
TREK-king the blood-brain-barrier. [PMID:24557892]	Bittner S, Ruck T, Fernández-Orth J, Meu	J Neuroimmune Pharmacol	2014	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral ed [PMID:41535708]	Yu MJ, Xiong RQ, Wu JW, Li YC, Xie JX et	Acta Pharmacol Sin	2026	0
NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopat [PMID:41650822]	López-Sampere Y, Mengod Soler P, Roca-Pe	Redox Biol	2026	0
Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt [PMID:41665955]	Qi F, Lennon VA, Zhao S, Guo Y, Ding H e	J Clin Invest	2026	0
Safety and efficacy of ravulizumab in patients with NMOSD previously treated wit [PMID:41782198]	Bennett JL, Bhattacharyya S, Zabeti A, L	Mult Scler	2026	0
Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387]	Elosua-Bayés I, Cobo-Calvo A	Rev Neurol (Paris)	2026	0
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462]	Tan Y, Ye H, Ge Q, Wang P, Liu Z et al.	J Magn Reson Imaging	2026	0
Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum di [PMID:41915816]	Jiang X, Chen J, Wen Y, Yuan L, Zhang J	The Journal of international m	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AQUAPORIN-4 in their description or question text

No additional research found