Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Alpha-Synuclein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Alpha-synuclein (SNCA/α-syn) is a 140-amino acid presynaptic protein that regulates synaptic vesicle trafficking, SNARE complex assembly, and neurotransmitter release. Misfolding and aggregation of α-synuclein into Lewy bodies is the pathological hallmark of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. The A53T, A30P, and E46K mutations cause familial Parkinson's.
Ontology: MESH:D000072881
No AI portrait yet
| Gene Symbol | alpha synuclein |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
| Target | Relation | Type | Str |
|---|---|---|---|
| amyloid beta | interacts_with | compound | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Alpha-Synuclein in their description or question text
No additional research found