Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer'S Disease | contributes_to | disease | 0.90 |
| Amyloid Beta | associated_with | protein | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Perindopril | inhibits | drug | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb | 0.743 | neurodegeneration | What are the physiological functions of |
| SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso | 0.734 | neurodegeneration | What molecular mechanisms link elevated |
| SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct | 0.732 | neurodegeneration | How do sphingomyelin/ceramide ratios spe |
| Palmitoylation-Targeted BACE1 Trafficking Disruptors | 0.693 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.743
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468] | ["Hsu-Heng Lin", "Hui-An Chen", "Shyh-Je | Molecular genetics & genom | 2026 | 0 |
| Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198] | ["Aron Park", "Baeki E Kang", "Eun-Ju Ji | Genes & genomics | 2026 | 0 |
| A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606] | Yu X MD, Lei J MSc, Du X MSc, He Y MSc, | Int J Surg | 2026 | 0 |
| Plasma metabolites may inhibit childhood obesity by regulating ferroptosis throu [PMID:41249848] | Wang JG, Pan XH, Li Y | Int J Obes (Lond) | 2026 | 0 |
| Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198] | Park A, Kang BE, Jin EJ, Kim HJ, Lee CW | Genes Genomics | 2026 | 0 |
| AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160] | Jia J, Gan Y, Li J, Li L, Meng H et al. | Adv Sci (Weinh) | 2026 | 0 |
| Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820] | Nishioka K, Ikezaki M, Iwahashi N, Araka | Life Sci Alliance | 2026 | 0 |
| Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468] | Lin HH, Chen HA, Lin SJ, Hsu RH, Lee NC | Mol Genet Genomic Med | 2026 | 0 |
| An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149] | Fang W, Zhao J, Li L, Wang Y, Xu ZP et a | Mater Today Bio | 2026 | 0 |
| Neuregulin1-ErbB4 Signaling Involved in Acupuncture Promoting Myelin Regeneratio [PMID:41801841] | Shen J, Zhao Y, Jiang C, Huang Y, Wang L | J Vis Exp | 2026 | 0 |
| Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110] | Natale Francesca; Dellaria Alice; Nifo S | Alzheimer's research & the | 2026 | 0 |
| Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874] | Xiao S, Han Y, Yan J, Wu L, Lin H et al. | Int Immunopharmacol | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in [PMID:41482106] | Kaur A, Singh S, Singh M, Silakari P, Ma | Experimental neurology | 2026 | 0 |
| AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160] | Jia J, Gan Y, Li J, Li L, Meng H, Sun M, | Advanced science (Weinheim, Ba | 2026 | 0 |
| A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606] | Yu X, Lei J, Du X, He Y, Peng W, Yang R, | International journal of surge | 2026 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J et a | CNS Neurosci Ther | 2025 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J, Yi | CNS neuroscience & therapeutic | 2025 | 0 |
| Proposed Therapeutic Strategy to Combat Alzheimer's Disease by Targeting Beta an [PMID:40491367] | ["Kumar D", "Anand P", "Singh S"] | Current Alzheimer research | 2025 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ACE1 in their description or question text
No additional research found