concept

AMYLOID PLAQUES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID PLAQUES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

28Outgoing

44Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AMYLOID PLAQUES
Key Genes/Proteins	ADAM10, AMYLOID, APOE, APOE4, APP
Related Diseases	ALZHEIMER'S DISEASE, CEREBRAL AMYLOID ANGIOPATHY

Pathway Diagram

graph TD
    AMYLOID_PLAQUES["AMYLOID PLAQUES"]
    AMYLOID_PLAQUES -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_S_Disease["Alzheimer'S Disease"]
    AMYLOID_PLAQUES -->|"correlates_with"| Lipid_Droplet_Load["Lipid Droplet Load"]
    AMYLOID_PLAQUES -->|"causes"| Neurodegeneration["Neurodegeneration"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_Disease["Alzheimer Disease"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    AMYLOID_PLAQUES -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    APP["APP"] -->|"causes"| AMYLOID_PLAQUES
    Amyloid_Beta["Amyloid Beta"] -->|"mediates"| AMYLOID_PLAQUES
    microglial_efferocytosis["microglial efferocytosis"] -->|"activates"| AMYLOID_PLAQUES
    alpha_synuclein["alpha-synuclein"] -->|"activates"| AMYLOID_PLAQUES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| AMYLOID_PLAQUES
    ASTROCYTES["ASTROCYTES"] -->|"interacts"| AMYLOID_PLAQUES
    MICROGLIA["MICROGLIA"] -->|"activates"| AMYLOID_PLAQUES
    Microglia_Replacement["Microglia Replacement"] -->|"suppresses"| AMYLOID_PLAQUES

Outgoing (28)

Target	Relation	Type	Str
Alzheimer's Disease	involved_in	disease	0.98
Alzheimer'S Disease	biomarker_for	disease	0.95
Lipid Droplet Load	correlates_with	phenotype	0.90
Alzheimer's Disease	associated_with	disease	0.90
Alzheimer's Disease	biomarker_for	disease	0.90
Neurodegeneration	causes	process	0.85
Alzheimer Disease	biomarker_for	disease	0.85
Complement Activation	associated_with	process	0.80
Mild Cognitive Impairment	biomarker_for	disease	0.80
Alzheimer's disease	biomarker_for	disease	0.70
NEUROINFLAMMATION	causes	phenotype	0.65
CEREBRAL AMYLOID ANGIOPATHY	causes	disease	0.65
CEREBRAL AMYLOID ANGIOPATHY	produces	disease	0.65
TAU	protects_against	protein	0.65
TAU	phosphorylates	protein	0.65
INFLAMMATION	causes	phenotype	0.65
NEURODEGENERATION	interacts_with	phenotype	0.65
ALZHEIMER'S DISEASE	produces	disease	0.65
METFORMIN	protects_against	drug	0.65
INFLAMMATION	produces	phenotype	0.65
ALZHEIMER'S DISEASE	expressed_in	disease	0.55
CA1	associated_with	brain_region	0.50
METFORMIN	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
LECANEMAB	associated_with	drug	0.45
ADUCANUMAB	associated_with	drug	0.45
DONANEMAB	associated_with	drug	0.45

Incoming (44)

Source	Relation	Type	Str
ABCA7 Deletion	upregulates	phenotype	0.95
APP	causes	gene	0.92
APP	associated_with	gene	0.90
Amyloid-β	associated_with	protein	0.90
Al002C	associated_with	drug	0.90
Amyloid Beta	mediates	protein	0.90
TREM2	associated_with	protein	0.88
SGMS1	associated_with	protein	0.88
Aged Microglia	associated_with	cell_type	0.80
microglial efferocytosis	activates	process	0.70
microglia	associated_with	cell_type	0.70
NEURODEGENERATION	inhibits	phenotype	0.70
NEURONS	regulates	cell_type	0.70
alpha-synuclein	activates	protein	0.70
AMYLOID	increases_risk	protein	0.65
ALZHEIMER'S DISEASE	inhibits	disease	0.65
MICROGLIA	causes	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
MICROGLIA	interacts_with	cell_type	0.65
PHAGOCYTOSIS	transports	phenotype	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
ASTROCYTES	interacts_with	cell_type	0.65
MICROGLIA	activates	cell_type	0.65
MICROGLIA	protects_against	cell_type	0.65
AMYLOID	inhibits	protein	0.65
ADAM10	interacts_with	gene	0.65
ADAM10	produces	gene	0.65
APP	degrades	gene	0.65
LECANEMAB	causes	drug	0.65
DONANEMAB	protects_against	drug	0.65
AMYLOID	causes	protein	0.65
APOE	inhibits	gene	0.65
APOE	regulates	gene	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
INFLAMMATION	expressed_in	phenotype	0.55
ADAM10	expressed_in	gene	0.55
AMYLOID	participates_in	protein	0.55
TAU	associated_with	protein	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.45
CEREBRAL CORTEX	associated_with	brain_region	0.45
APOE4	associated_with	gene	0.45
APOE	associated_with	gene	0.45
BDNF	interacts_with	gene	0.40
Microglia Replacement	suppresses	process	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity