protein 1,583 words KG: TRAF6
Contents

TRAF6 Protein

🔬 Protein Info
Gene SymbolTRAF6
Chromosome11p12
Protein TypeGene
FunctionTRAF6 is a central signaling molecule in multiple pathways
Molecular Weight60 kDa
Amino Acids524 aa
PathwaysNF-κB signaling, NF-κB, MAPK
GeneCardsTRAF6
Human Protein AtlasTRAF6
Associated DiseasesAls, Atherosclerosis, Autoimmune, Cancer, Encephalitis, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsACVR1, AD, AKT, AKT1, AMPK, AND
KG Connections672 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Astrocytes
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AKT1 Gene
gene · KG edge: activates
ATG7 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

TRAF6 associated_with MTOR
TRAF6 associated_with CHOP
TRAF6 associated_with NRF2
BAX associated_with TRAF6
FIS1 associated_with TRAF6
TRAF6 associated_with BECLIN1
TRAF6 associated_with BCL2
TRAF6 associated_with TAAR1
TRAF6 associated_with SIGMAR1
TRAF6 associated_with MYD88

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