| Gene Symbol | GRM8 |
| Full Name | Glutamate Metabotropic Receptor 8 |
| Chromosome | 7q31.3 |
| Protein Type | Receptor |
| Function | The GRM8 gene encodes metabotropic glutamate receptor 8 (mGluR8), a class C G-protein coupled receptor that functions as a presynaptic autoreceptor inhibiting glutamate release. |
| Primary Expression | brain regions involved in anxiety and fear processing (amygdala, hippocampus) |
| UniProt ID | [Q9URF5](https://www.uniprot.org/uniprotkb/Q9URF5/entry) |
| Ensembl ID | ENSG00000128514 |
| GeneCards | GRM8 |
| Human Protein Atlas | GRM8 |
| Associated Diseases | Als |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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