gene 1,345 words KG: RIN3
Contents

RIN3 — Rho GTPase-Activating Protein 25

🧬 Gene Info
Gene SymbolRIN3
Full NameRho GTPase-Activating Protein 25
Chromosome14q32.12
Protein FamilyRho GTPase-activating proteins
Functionencodes a Rho GTPase-activating protein that specifically regulates Rho family small GTPases, particularly Rac1 and Cdc42.
Primary Expressiondopaminergic neurons
Subcellular LocalizationRIN3 shows distinct localization patterns:
Amino Acids922 aa
UniProt IDQ8WU66
NCBI Gene ID154796
Ensembl IDENSG00000155097
OMIM614086
GeneCardsRIN3
Human Protein AtlasRIN3
CytoplasmicPrimary cellular distribution
Associated DiseasesAls, Alzheimer, Ms
InteractionsABCA7, BIN1, CASS4, CD2AP, CD33, CELF1
KG Connections52 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ABCA7 (Redirect)
redirect · KG edge: associated_with
SORL1 (Redirect)
redirect · KG edge: associated_with
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
Genes
index · KG edge: associated_with

Knowledge Graph (12 edges)

PLD3 associated_with RIN3
ABCA7 associated_with RIN3
SORL1 associated_with RIN3
PICALM associated_with RIN3
CR1 associated_with RIN3
TREM2 associated_with RIN3
CASS4 associated_with RIN3
CD33 associated_with RIN3
NME8 associated_with RIN3
BIN1 associated_with RIN3

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