gene 2,912 words KG: SORL1
Contents

SORL1 Gene

🧬 Gene Info
Gene SymbolSORL1
Full NameSortilin-Related Receptor 1 (Sorterin)
AliasesSortilin-Related Receptor 1
Chromosome11q23.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain, particularly in neurons of the hippocampus, cortex, and cerebel
Molecular Weight250 kDa
Amino Acids214 aa
Exons48
PathwaysAmyloid, Blood-Brain Barrier, Dysbiosis, Endocytosis, Epigenetic
UniProt IDQ92606
NCBI Gene ID6653
Ensembl IDENSG00000137642
OMIM602215
GeneCardsSORL1
Human Protein AtlasSORL1
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease
InteractionsABCA7, ABCB1, ACE, Actin, ALZHEIMER, ALZHEIMER DISEASE
KG Connections731 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
pg 1/2Next →

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (8)

ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SOAT1 associated_with SORL1
SORL1 associated_with LRP12
PRKN interacts_with SORL1
SORL1 interacts_with BACE1
SORL1 interacts_with APP
SORL1 interacts_with APOE
SORL1 interacts_with TAU
SORL1 interacts_with SNCA
SORL1 interacts_with SNCAIP
SORL1 interacts_with GSK3B

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.